cytosine deaminase activity

Known as: cytosine aminohydrolase activity, isocytosine deaminase activity 
Catalysis of the reaction: cytosine + H2O = uracil + NH3. [EC:3.5.4.1]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2017
02419702017

Papers overview

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Highly Cited
2014
Highly Cited
2014
APOBEC3B cytosine deaminase activity has recently emerged as a significant mutagenic factor in human cancer. APOBEC activity is… (More)
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2013
2013
Apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G (i.e., APOBEC3G or A3G) is an evolutionarily conserved… (More)
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Highly Cited
2010
Highly Cited
2010
The mammalian APOBEC3 proteins are an important component of the cellular innate immune response to retroviral infection… (More)
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2009
2009
Matrix attachment therapy (MAT) is an enzyme prodrug strategy that targets hyaluronan in the tumor extracellular matrix to… (More)
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2003
2003
An unusual interaction between flucytosine and fluconazole was observed when a collection of 60 Candida lusitaniae clinical… (More)
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Highly Cited
2000
Highly Cited
2000
Direct transfer of prodrug activation systems into tumors was demonstrated to be an attractive method for the selective in vivo… (More)
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1997
1997
By functional complementation of a fcy1 null mutant of Saccharomyces cerevisiae, we have cloned and characterized the FCY1 gene… (More)
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1978
1978
Previous work has suggested that 1-beta-D-arabinofuranosylcytosine 5'-triphosphate is the active metabolite of 1-beta-D… (More)
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1973
1973
The active forms of 6-(p-hydroxyphenylazo)-uracil and 6-(p-hydroxyphenylazo)-isocytosine were isolated and identified as their… (More)
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1970
1970
Mutants resistant to 5-fluorouracil, 5-fluorocytosine, and 5-fluorouridine were selected in yeast, and the mechanisms of their… (More)
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