S. Fahrenkrug

Publications115
h-index33
Citations4,228
Highly Influential Citations196
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In vivo Genome Editing Using High Efficiency TALENs
The zebrafish (Danio rerio) is increasingly being used to study basic vertebrate biology and human disease with a rich array of in vivo genetic and molecular tools. However, the inability to readily… Expand
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Efficient TALEN-mediated gene knockout in livestock
Transcription activator-like effector nucleases (TALENs) are programmable nucleases that join FokI endonuclease with the modular DNA-binding domain of TALEs. Although zinc-finger nucleases enable a… Expand
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Genetic immunization of rainbow trout (Oncorhynchus mykiss) against infectious hematopoietic necrosis virus.
Plasmid vectors encoding the infectious hematopoietic necrosis virus (IHNV) nucleoprotein or glycoprotein gene under the control of a cytomegalovirus promoter were used to immunize rainbow trout… Expand
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Efficient nonmeiotic allele introgression in livestock using custom endonucleases
Significance Selective breeding has long been practiced to enrich for desirable DNA variation that influences livestock traits. We demonstrate that genetic variants can be directly introgressed into… Expand
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Genome edited sheep and cattle
Genome editing tools enable efficient and accurate genome manipulation. An enhanced ability to modify the genomes of livestock species could be utilized to improve disease resistance, productivity or… Expand
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Live pigs produced from genome edited zygotes
Transcription activator-like effector nuclease (TALEN) and zinc finger nuclease (ZFN) genome editing technology enables site directed engineering of the genome. Here we demonstrate for the first time… Expand
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Two Zebrafish eIF4E Family Members Are Differentially Expressed and Functionally Divergent*
Eukaryotic translation initiation factor 4E (eIF4E) is an essential component of the translational machinery that binds m7GTP and mediates the recruitment of capped mRNAs by the small ribosomal… Expand
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Porcine gene discovery by normalized cDNA-library sequencing and EST cluster assembly
Genetic and environmental factors affect the efficiency of pork production by influencing gene expression during porcine reproduction, tissue development, and growth. The identification and… Expand
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DANA elements: a family of composite, tRNA-derived short interspersed DNA elements associated with mutational activities in zebrafish (Danio rerio).
DNA is the first SINE isolated from zebrafish (Danio rerio) exhibiting all the hallmarks of these tRNA-derived elements. DANA is unique in its clearly defined substructure of distinct cassettes. In… Expand
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The zebrafish thyroid hormone receptor alpha 1 is expressed during early embryogenesis and can function in transcriptional repression.
Nuclear receptors are a large family of ligand dependent transcription factors which participate in many diverse processes during development. In this report, we describe the cloning of the zebrafish… Expand
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