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cysmethynil

National Institutes of Health

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2018
2018
Inhibition of isoprenylcysteine carboxylmethyltransferase sensitizes common chemotherapies in cervical cancer via Ras-dependent pathway.
2018
2018
Isoprenylcysteine carboxylmethyltransferase regulates ovarian cancer cell response to chemotherapy and Ras activation.
2009
2009
Analogues of cysmethynil that demonstrate improved isoprenylcysteine carboxymethyltransferase (Icmt) inhibition activity and antiproliferative activity in MDA‐MB‐231 breast cancer cells
Many eukaryotic proteins, such as the Ras family of GTPases, contain a C‐terminal CAAX motif which directs the proteins through a… 
2007
2007
Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase.
2007
2007
Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules.
Isoprenylcysteine carboxyl methyltransferase (Icmt) catalyzes the methylation of the C-terminal prenylcysteine found on… 
2006
2006
Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function.
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