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A Conserved Family of Enzymes That Phosphorylate Inositol Hexakisphosphate
Inositol pyrophosphates are a diverse group of high-energy signaling molecules whose cellular roles remain an active area of study. We report a previously uncharacterized class of inositol… Expand
Cloning and Characterization of Two Human VIP1-like Inositol Hexakisphosphate and Diphosphoinositol Pentakisphosphate Kinases*
- Peter C Fridy, J. Otto, D. E. Dollins, J. York
- Biology, Medicine
- Journal of Biological Chemistry
- 19 October 2007
Eukaryotes possess numerous inositol phosphate (IP) and diphosphoinositol phosphate (PP-IPs or inositol pyrophosphates) species that act as chemical codes important for intracellular signaling… Expand
Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2 (*)
- I. Morita, M. Schindler, +4 authors W. Smith
- Biology, Medicine
- The Journal of Biological Chemistry
- 5 May 1995
The subcellular locations of prostaglandin endoperoxide synthase-1 and −2 (PGHS-1 and −2) were determined by quantitative confocal fluorescence imaging microscopy in murine 3T3 cells and human and… Expand
Prostaglandin endoperoxide synthases-1 and -2.
Publisher Summary The chapter compares and contrasts the structural and kinetic properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and -2. It also discusses the description of the… Expand
Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice*
- M. Bergo, G. K. Leung, +5 authors S. Young
- Biology, Medicine
- The Journal of Biological Chemistry
- 23 February 2001
After isoprenylation, Ras and other CAAX proteins undergo endoproteolytic processing by Rce1 and methylation of the isoprenylcysteine by Icmt (isoprenylcysteine carboxyl methyltransferase). We… Expand
Disruption of the Mouse Rce1 Gene Results in Defective Ras Processing and Mislocalization of Ras within Cells*
- E. Kim, P. Ambroziak, +5 authors S. Young
- Biology, Medicine
- The Journal of Biological Chemistry
- 26 March 1999
Little is known about the enzyme(s) required for the endoproteolytic processing of mammalian Ras proteins. We identified a mouse gene (designated Rce1) that shares sequence homology with a yeast gene… Expand
N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.
Using site-directed mutagenesis, we have determined that Asn68, Asn144, and Asn410 of ovine prostaglandin endoperoxide (PGH) synthase-1 are N-glycosylated. A fourth consensus N-glycosylation sequence… Expand
The Hepatitis Delta Virus Large Antigen Is Farnesylated Both in Vitro and in Animal Cells (*)
The hepatitis delta virus large antigen (lHDAg) is a virally encoded protein that contains a prenylation signal sequence at its carboxyl terminus consisting of the tetrapeptide Cys-Arg-Pro-Gln.… Expand
Assessment of the usefulness of ribosomal 18S and mitochondrial COI sequences in Prostigmata phylogeny.
- J. Otto, K. Wilson, +4 authors M. Colloff
- Biology
- 2001
- 56
- 5
Cloning and Characterization of a Mammalian Prenyl Protein-specific Protease*
- J. Otto, E. Kim, S. Young, P. Casey
- Biology, Medicine
- The Journal of Biological Chemistry
- 26 March 1999
Proteins containing C-terminal “CAAX” sequence motifs undergo three sequential post-translational processing steps: modification of the cysteine with either a 15-carbon farnesyl or 20-carbon… Expand