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A Conserved Family of Enzymes That Phosphorylate Inositol Hexakisphosphate
Inositol pyrophosphates are a diverse group of high-energy signaling molecules whose cellular roles remain an active area of study. We report a previously uncharacterized class of inositolExpand
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Cloning and Characterization of Two Human VIP1-like Inositol Hexakisphosphate and Diphosphoinositol Pentakisphosphate Kinases*
Eukaryotes possess numerous inositol phosphate (IP) and diphosphoinositol phosphate (PP-IPs or inositol pyrophosphates) species that act as chemical codes important for intracellular signalingExpand
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Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2 (*)
The subcellular locations of prostaglandin endoperoxide synthase-1 and −2 (PGHS-1 and −2) were determined by quantitative confocal fluorescence imaging microscopy in murine 3T3 cells and human andExpand
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Prostaglandin endoperoxide synthases-1 and -2.
  • J. Otto, W. Smith
  • Biology, Medicine
  • Journal of lipid mediators and cell signalling
  • 1 October 1995
Publisher Summary The chapter compares and contrasts the structural and kinetic properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and -2. It also discusses the description of theExpand
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Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice*
After isoprenylation, Ras and other CAAX proteins undergo endoproteolytic processing by Rce1 and methylation of the isoprenylcysteine by Icmt (isoprenylcysteine carboxyl methyltransferase). WeExpand
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Disruption of the Mouse Rce1 Gene Results in Defective Ras Processing and Mislocalization of Ras within Cells*
Little is known about the enzyme(s) required for the endoproteolytic processing of mammalian Ras proteins. We identified a mouse gene (designated Rce1) that shares sequence homology with a yeast geneExpand
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N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.
Using site-directed mutagenesis, we have determined that Asn68, Asn144, and Asn410 of ovine prostaglandin endoperoxide (PGH) synthase-1 are N-glycosylated. A fourth consensus N-glycosylation sequenceExpand
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The Hepatitis Delta Virus Large Antigen Is Farnesylated Both in Vitro and in Animal Cells (*)
  • J. Otto, P. Casey
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1 March 1996
The hepatitis delta virus large antigen (lHDAg) is a virally encoded protein that contains a prenylation signal sequence at its carboxyl terminus consisting of the tetrapeptide Cys-Arg-Pro-Gln.Expand
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Cloning and Characterization of a Mammalian Prenyl Protein-specific Protease*
Proteins containing C-terminal “CAAX” sequence motifs undergo three sequential post-translational processing steps: modification of the cysteine with either a 15-carbon farnesyl or 20-carbonExpand
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