Protein prenylation: molecular mechanisms and functional consequences.
The emphasis in this review is on the enzymology of prenyl protein processing and the functional significance ofPrenylation in cellular events.
Post-prenylation-processing enzymes as new targets in oncogenesis
Findings indicate that the inhibition of these post-prenylation-processing steps — particularly that of ICMT-catalysed methylation — might provide a better approach to the control of cancer-cell proliferation.
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.
The rate and extent of the agonist-dependent phosphorylation of beta 2-adrenergic receptors and rhodopsin by Beta ARK are markedly enhanced on addition of G protein beta gamma subunits, suggesting that the enzyme preferentially binds specific beta gamma complexes.
Protein lipidation in cell signaling.
- P. Casey
- 14 April 1995
The ability of cells to communicate with and respond to their external environment is critical for their continued existence. A universal feature of this communication is that the external signal…
Inhibition of purified p21 ras farnesyl:protein transferase by Cys-AAX tetrapeptides
p21ras is modified by a farnesyl isoprenoid.
- P. Casey, P. A. Solski, C. Der, J. Buss
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 November 1989
It is reported that the processing of ras proteins involves addition of a farnesyl moiety, apparently at the COOH-terminal Cysteine analogous to the cysteine modified in the yeast peptides, and that farNESylation may be important for membrane association and transforming activity of rAS proteins.
Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins.
This review focuses on the biochemical properties and signalling of those G-proteins historically classified as 'PTX-resistant' due to the inability of the toxin to influence signalling through them, including members of the Gq and G12 families and one Gi family member, i.e. Gz.
Crystal Structure of Protein Farnesyltransferase at 2.25 Angstrom Resolution
- Hee-won Park, Sobha R. Boduluri, J. Moomaw, P. Casey, L. Beese
- Chemistry, BiologyScience
- 21 March 1997
The crystal structure of heterodimeric mammalian FTase was determined at 2.25 angstrom resolution and shows a combination of two unusual domains: a crescent-shaped seven-helical hairpin domain and an α-α barrel domain.
Farnesyltransferase Inhibitors Alter the Prenylation and Growth-stimulating Function of RhoB*
- P. Lebowitz, P. Casey, G. Prendergast, J. Thissen
- Biology, ChemistryJournal of Biological Chemistry
- 20 June 1997
These findings strengthen the causal link between RhoB inhibition and the anti-transforming effects of FTIs and indicate that differently prenylated forms of R HoB may have unique functions.