cyclopamine

Known as: 4'-Nitro-3-Nitroflavone, R8122, 3-Nitro-2-(4-nitrophenyl)-4H-1-benzopyran-4-one 
 
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Brain tumors can arise following deregulation of signaling pathways normally activated during brain development and may derive… (More)
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Highly Cited
2005
Highly Cited
2005
The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedgehog (Hh) pathway has hinted at a… (More)
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Highly Cited
2004
Highly Cited
2004
Hedgehog (Hh) signalling controls many aspects of development. It also regulates cell growth and differentiation in adult tissues… (More)
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Highly Cited
2003
Highly Cited
2003
Hedgehog signalling—an essential pathway during embryonic pancreatic development, the misregulation of which has been implicated… (More)
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Highly Cited
2002
Highly Cited
2002
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block… (More)
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Highly Cited
2002
Highly Cited
2002
Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic… (More)
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Highly Cited
2002
Highly Cited
2002
Constitutive Hedgehog (Hh) pathway activity is associated with initiation of neoplasia, but its role in the continued growth of… (More)
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Highly Cited
2000
Highly Cited
2000
Basal cell carcinoma, medulloblastoma, rhabdomyosarcoma and other human tumours are associated with mutations that activate the… (More)
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Highly Cited
1998
Highly Cited
1998
The steroidal alkaloid cyclopamine produces cyclopia and holoprosencephaly when administered to gastrulation-stage amniote… (More)
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Highly Cited
1998
Highly Cited
1998
Exposure to cyclopamine, a steroid alkaloid that blocks Sonic hedgehog (Shh) signaling, promotes pancreatic expansion in… (More)
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