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cyclopamine

Known as: 4'-Nitro-3-Nitroflavone, R8122, 3-Nitro-2-(4-nitrophenyl)-4H-1-benzopyran-4-one 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Veratrum Alkaloids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Neural patterning of human induced pluripotent stem cells in 3-D cultures for studying biomolecule-directed differential cellular responses.
2012
2012
Off-Target Function of the Sonic Hedgehog Inhibitor Cyclopamine in Mediating Apoptosis via Nitric Oxide–Dependent Neutral Sphingomyelinase 2/Ceramide Induction
Sonic hedgehog (SHh) signaling is important in the pathogenesis of various human cancers, such as medulloblastomas, and it has… 
2010
2010
Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer
Activation of the hedgehog (HH) pathway plays a critical role in the development and continued growth of pancreatic… 
Highly Cited
2009
Highly Cited
2009
Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells.
BACKGROUND Hedgehog (Hh) and Wnt signaling pathways are involved in the stimulation of growth of leukemia and lymphoma cells. In… 
2009
2009
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.
Highly Cited
2007
Highly Cited
2007
Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer…
The epidermal growth factor receptor (EGFR) and hedgehog cascades provide a critical role in prostate cancer progression and… 
Highly Cited
2006
Highly Cited
2006
Regulation of Gremlin expression in the posterior limb bud.
2006
2006
Sonic hedgehog stimulates the proliferation of rat gastric mucosal cells through ERK activation by elevating intracellular calcium concentration.
Highly Cited
2003
Highly Cited
2003
Extraretinal and retinal hedgehog signaling sequentially regulate retinal differentiation in zebrafish.
1995
1995
Cyclopamine, a steroidal alkaloid, disrupts development of cranial neural crest cells in Xenopus
Cyclopamine is a steroidal alkaloid which causes limb and craniofacial defects in many vertebrate species. We have used Xenopus… 
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