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cyclopamine

Known as: 4'-Nitro-3-Nitroflavone, R8122, 3-Nitro-2-(4-nitrophenyl)-4H-1-benzopyran-4-one 
National Institutes of Health

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Related topics

1 relation

Broader (1)

Veratrum Alkaloids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
The role of the Hedgehog signaling pathway in cancer: A comprehensive review.
The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a highly conserved evolutionary pathway… 
Highly Cited
2007
Highly Cited
2007
Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma
Brain tumors can arise following deregulation of signaling pathways normally activated during brain development and may derive… 
Highly Cited
2007
Highly Cited
2007
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
The developmentally important Hedgehog (Hh) signaling pathway has recently been implicated in several forms of solid cancer… 
Highly Cited
2005
Highly Cited
2005
Vertebrate Smoothened functions at the primary cilium
The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedgehog (Hh) pathway has hinted at a… 
Review
2005
Review
2005
Non-melanoma skin cancer: what drives tumor development and progression?
Non-melanoma skin cancer, i.e. basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent tumors and… 
Highly Cited
2003
Highly Cited
2003
BMP‐2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop
Wnt/β‐catenin signaling has recently been suggested to be involved in bone biology. The precise role of this cascade in… 
Highly Cited
2003
Highly Cited
2003
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
Hedgehog signalling—an essential pathway during embryonic pancreatic development, the misregulation of which has been implicated… 
Highly Cited
2003
Highly Cited
2003
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
Activation of the Hedgehog (Hh) signalling pathway by sporadic mutations or in familial conditions such as Gorlin's syndrome is… 
Highly Cited
2002
Highly Cited
2002
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block… 
Highly Cited
1998
Highly Cited
1998
Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor.
Exposure to cyclopamine, a steroid alkaloid that blocks Sonic hedgehog (Shh) signaling, promotes pancreatic expansion in… 
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