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Bile acids: natural ligands for an orphan nuclear receptor.
TLDR
Results provide evidence for a nuclear bile acid signaling pathway that may regulate cholesterol homeostasis and modulated interaction of FXR with a peptide derived from steroid receptor coactivator 1.
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.
TLDR
The results suggest that strategies aimed at increasing FXR activity and the repressive effects of SHP should be explored to correct hypertriglyceridemia.
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
TLDR
It is shown that the nuclear receptor CAR mediates the response evoked by a class of xenobiotics known as the ‘phenobarbital-like inducers’, and loss of CAR function alters sensitivity to toxins, increasing or decreasing it depending on the compound.
A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.
TLDR
It is proposed that MB67 plays an important role in the complex network of proteins that govern response to retinoic acid and its metabolites.
Farnesoid X receptor is essential for normal glucose homeostasis.
TLDR
A link between lipid and glucose metabolism mediated by the FXR-SHP cascade is identified, and bile acid activation of FXR in WT mice repressed expression of gluconeogenic genes and decreased serum glucose.
An Orphan Nuclear Hormone Receptor That Lacks a DNA Binding Domain and Heterodimerizes with Other Receptors
TLDR
In mammalian cells, SHP specifically inhibited transactivation by the superfamily members with which it interacted, suggesting that SHP functions as a negative regulator of receptor-dependent signaling pathways.
Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration
TLDR
It is proposed that FXR activation by increased bile acid flux is a signal of decreased functional capacity of the liver, and may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth.
Interactions between Hepatic Mrp4 and Sult2a as Revealed by the Constitutive Androstane Receptor and Mrp4 Knockout Mice*
TLDR
It is suggested that Mrp4 and Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver in order to protect the liver from accumulation of hydrophobic bile acids.
The Xenobiotic Compound 1,4-Bis[2-(3,5-Dichloropyridyloxy)]Benzene Is an Agonist Ligand for the Nuclear Receptor CAR
TLDR
It is shown that the nuclear receptor CAR can recognize response elements present in the promoters of xenobiotic-responsive CYP genes, as well as other novel sites, to demonstrate that CAR is a novel xenobiotics receptor that may contribute to the metabolic response to such compounds.
A Natural Product That Lowers Cholesterol As an Antagonist Ligand for FXR
TLDR
It is proposed that inhibition of FXR activation is the basis for the cholesterol-lowering activity of guggulsterone, a highly efficacious antagonist of the farnesoid X receptor (FXR), a nuclear hormone receptor that is activated by bile acids.
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