• Publications
  • Influence
Bile acids: natural ligands for an orphan nuclear receptor.
Bile acids regulate the transcription of genes that control cholesterol homeostasis through molecular mechanisms that are poorly understood. Physiological concentrations of free and conjugatedExpand
  • 1,767
  • 94
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.
We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination of molecular, cellular, and animal models. Cholic acid (CA) prevents hepatic TG accumulation, VLDLExpand
  • 897
  • 66
  • PDF
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
Organisms encounter a wide range of foreign compounds—or ‘xenobiotics’—with potentially harmful consequences. The cytochrome P450 (CYP) enzymes metabolize xenobiotics and thus are a primary defenceExpand
  • 605
  • 39
A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.
We have identified and characterized a new orphan member of the nuclear hormone receptor superfamily, called MB67, which is predominantly expressed in liver. MB67 binds and transactivates theExpand
  • 477
  • 39
Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration
Liver mass depends on one or more unidentified humoral signals that drive regeneration when liver functional capacity is diminished. Bile acids are important liver products, and their levels areExpand
  • 542
  • 37
Farnesoid X receptor is essential for normal glucose homeostasis.
The bile acid receptor farnesoid X receptor (FXR; NR1H4) is a central regulator of bile acid and lipid metabolism. We show here that FXR plays a key regulatory role in glucose homeostasis. FXR-nullExpand
  • 626
  • 36
  • PDF
An Orphan Nuclear Hormone Receptor That Lacks a DNA Binding Domain and Heterodimerizes with Other Receptors
SHP is an orphan member of the nuclear hormone receptor superfamily that contains the dimerization and ligand-binding domain found in other family members but lacks the conserved DNA binding domain.Expand
  • 502
  • 33
Interactions between Hepatic Mrp4 and Sult2a as Revealed by the Constitutive Androstane Receptor and Mrp4 Knockout Mice*
The ABC transporter, Mrp4, transports the sulfated steroid DHEA-s, and sulfated bile acids interact with Mrp4 with high affinity. Hepatic Mrp4 levels are low, but increase under cholestaticExpand
  • 217
  • 29
  • PDF
A Natural Product That Lowers Cholesterol As an Antagonist Ligand for FXR
Extracts of the resin of the guggul tree (Commiphora mukul) lower LDL (low-density lipoprotein) cholesterol levels in humans. The plant sterol guggulsterone [4,17(20)-pregnadiene-3,16-dione] is theExpand
  • 447
  • 25