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cycloartenol synthase activity

Known as: (S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming), 2,3-oxidosqualene-cycloartenol cyclase activity, 2,3-epoxysqualene--cycloartenol cyclase activity 
Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol. [EC:5.4.99.8, RHEA:21311]
National Institutes of Health

Papers overview

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2018
2018
Cloning and functional analysis of two sterol-C24-methyltransferase 1 (SMT1) genes from Paris polyphylla
Abstract The biosynthetic pathways of phytosterols and steroidal saponins are located in two adjacent branches which share… Expand
2014
2014
New 9,19-cycloartenol glycosides isolated from the roots of Cimicifuga simplex and their anti-inflammatory effects.
Two new cycloartenol triterpene saponins, 3β,16α-dihydroxy-12-acetoxy-16,22-cyclo-23-ketone-24R,25-epoxy-cycloartane-3-O-β-D… Expand
2012
2012
Three new cycloartenol glycosides from the roots of Cimicifuga simplex.
Three new cycloartenol triterpene saponins, 3 β,16 α-dihydroxy-12-acetoxy-16,22-cyclo-23-ketone-24 R,25-epoxy-cycloartane-7-ene 3… Expand
2011
2011
Three New Cycloartenol Triterpenoid Saponins from the Roots of Cimicifuga simplex Wormsk
Three new cycloartenol triterpene saponins, named shengmaxinsides A-C, have been isolated from the ethyl acetate soluble fraction… Expand
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2005
2005
Isolierung von Cycloartenol aus Blättern der Kulturkartoffel,Solanum tuberosum L.
ZusammenfassungAus Blättern der Kartoffelpflanze,Solanum tuberosum L., wurde das Triterpen Cycloartenol (9β.19-Cyclo-lanost-24-en… Expand
2002
2002
Conversion of a plant oxidosqualene-cycloartenol synthase to an oxidosqualene-lanosterol cyclase by random mutagenesis.
A random mutagenesis/in vivo selection approach was applied to generate and identify mutations that alter the product specificity… Expand
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Highly Cited
2000
Highly Cited
2000
Molecular cloning and characterization of a cDNA for Glycyrrhiza glabra cycloartenol synthase.
A cDNA clone (GgCAS1) encoding cycloartenol synthase (CAS) has been isolated from Glycyrrhiza glabra (licorice) by cross… Expand
1987
1987
Use of rationally designed inhibitors to study sterol and triterpenoid biosynthesis
Several enzymes of plant sterol or triterpenoid biosynthesis involve during their catalysis postulated or demonstrated… Expand
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Highly Cited
1984
Highly Cited
1984
Inhibition of S-adenosyl-L-methionine sterol-C-24-methyltransferase by analogues of a carbocationic ion high-energy intermediate. Structure activity relationships for C-25 heteroatoms (N, As, S…
Microsomes from maize seedlings are capable of catalyzing the C-24 alkylation of 4,4,14 alpha-trimethyl-9 beta,19-cyclo-5 alpha… Expand
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1983
1983
Inhibition of 2,3-oxidosqualene: beta-amyrin-cyclase, S-adenosyl-L-methionine: cycloartenol C-24-methyltransferase and cycloeucalenol: obtusifoliol isomerase by rationally designed molecules…
25-Azacycloartanol (I), 2-aza-2-dihydrosqualene (II) and Tridemorph (2,6-dimethyl-N-tridecylmorpholine) (III) are potent… Expand
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