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cullin-RING ubiquitin ligase complex

Known as: cullin complex location, CRL complex location, cullin-RING ubiquitin ligase complex location 
Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated… Expand
National Institutes of Health

Related topics

Related topics

1 relation
SCF ubiquitin ligase complex

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation.
Cullin 4B (CUL4B) is a scaffold protein that assembles cullin-RING ubiquitin ligase (E3) complexes. Recent studies have revealed… Expand
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Highly Cited
2010
Highly Cited
2010
HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.
The human immunodeficiency virus type 1 (HIV-1) accessory protein, Vpr, interacts with several host cellular proteins including… Expand
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Highly Cited
2007
Highly Cited
2007
HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4AVPRBP E3 Ubiquitin Ligase
Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has been shown to cause G2 cell cycle arrest in human cells by… Expand
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Highly Cited
2006
Highly Cited
2006
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.
Xeroderma pigmentosum (XP) is a heritable human disorder characterized by defects in nucleotide excision repair (NER) and the… Expand
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Highly Cited
2006
Highly Cited
2006
A zinc-binding region in Vif binds Cul5 and determines cullin selection.
Human immunodeficiency virus-1 (HIV-1) Vif overcomes the anti-viral activity of APOBEC3G by targeting it for ubiquitination via a… Expand
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Highly Cited
2006
Highly Cited
2006
Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC.
Xeroderma pigmentosum (XP) complementation group E gene product, damaged DNA-binding protein 2 (DDB2), is a subunit of the DDB… Expand
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Highly Cited
2005
Highly Cited
2005
DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.
Xeroderma pigmentosum (XP) is a genetic disease characterized by hypersensitivity to UV irradiation and high incidence of skin… Expand
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Highly Cited
2004
Highly Cited
2004
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.
Arabidopsis thaliana De-etiolated-1 (AtDET1) is a highly conserved protein, with orthologs in vertebrate and invertebrate… Expand
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Highly Cited
2002
Highly Cited
2002
Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components.
Signal transducer and activator of transcription (STAT) proteins are normally long-lived, but infection with certain… Expand
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Highly Cited
1999
Highly Cited
1999
Cullin 4A associates with the UV-damaged DNA-binding protein DDB.
The damaged DNA-binding protein (DDB) is believed to be involved in DNA repair, and it has been linked to the repair deficiency… Expand
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