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cruzain

National Institutes of Health

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caspase

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2017
2017
Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study
A series of semicarbazone, thiosemicarbazone, and aminoguanidine derivatives were synthesized and tested as antitrypanosomal… 
2017
2017
Molecular modeling and structure–activity relationships studies of bioisoster hybrids of N-acylhydrazone and furoxan groups on cruzain
Chagas disease is a very important neglected disease and millions of people live in endemic areas at the risk of acquiring the… 
2013
2013
Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor
Cruzain is the major cysteine protease of Trypanosoma cruzi, the infectious agent responsible for Chagas disease, and cruzain… 
2008
2008
2D QSAR and similarity studies on cruzain inhibitors aimed at improving selectivity over cathepsin L.
2008
2008
Uncovering false positives on a virtual screening search for cruzain inhibitors.
2007
2007
Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain.
The dipeptidyl epoxyesters 3 and 4 are potent, irreversible inhibitors of cruzain and rhodesain. 
2005
2005
Probing the cruzain S2 recognition subsite: a kinetic and binding energy calculation study.
Cysteine proteases are relevant to several aspects of the parasite life cycle and the parasite-host relationship. Moreover, they… 
2001
2001
S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids.
We have explored the substrate specificity of a recombinant cysteine proteinase of Leishmania mexicana (CPB2.8 Delta CTE) in… 
2001
2001
Analysis of the S(2) subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural…
1998
1998
Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain.
The dipeptidyl epoxy ketone 4 is a potent, irreversible inhibitor of cruzain, a cysteine protease isolated from Trypanosoma cruzi… 
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