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crisnatol mesylate
An anticancer drug that interferes with the DNA in cancer cells.
National Institutes of Health
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crisnatol
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2004
2004
Microbial Production of a Crisnatol Metabolite
C. D. Hufford
,
S. El-Sharkawy
,
T. Jurgens
,
J. R. Mikell
Pharmaceutical Research
2004
Corpus ID: 26331841
Microbial metabolism studies of crisnatol (1), a new DNA interca-lator, has resulted in the isolation and characterization of a…
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2004
2004
A phase II study of crisnatol mesylate in patients with ovarian carcinoma
R. Smalley
,
D. Goldstein
,
+4 authors
R. Tuttle
Investigational New Drugs
2004
Corpus ID: 22450618
SummaryFourteen patients with advanced ovarian cancer received a 72 hour infusion of a new DNA intercalator, crisnatol mesylate…
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2004
2004
Crisnatol mesylate: Phase I dose escalation by extending infusion duration
E. Poplin
,
G. Chabot
,
R. Tuttle
,
S. Lucas
,
W. Wargin
,
L. Baker
Investigational New Drugs
2004
Corpus ID: 888636
SummaryCrisnatol mesylate is a rationally designed cytotoxic arylmethylamino-propanediol with broad spectrum cytotoxic activity…
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1999
1999
A phase I and pharmacological study of protracted infusions of crisnatol mesylate in patients with solid malignancies.
M. Villalona-Calero
,
T. Petit
,
+8 authors
E. Rowinsky
Clinical cancer research : an official journal of…
1999
Corpus ID: 6550727
This Phase I and pharmacological study was performed to assess the feasibility of administering the polycyclic aromatic…
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1997
1997
Long-term response to crisnatol mesylate in patients with glioma.
P. New
,
E. Vokes
,
+4 authors
P. Vilk
Investigational new drugs
1997
Corpus ID: 27883424
A total of 26 patients (6 with anaplastic astrocytoma; 20 with glioblastoma) were treated with crisnatol mesylate. All patients…
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1990
1990
Evaluation of arylmethylaminopropanediols by a novel in vitro pharmacodynamic assay: correlation with antitumor activity in vivo.
D. Adams
,
P. Watkins
,
V. Knick
,
R. Tuttle
,
K. Bair
Cancer research
1990
Corpus ID: 22129902
The pharmacodynamics of a new series of antitumor DNA intercalators, known as arylmethylaminopropanediols (AMAPs), has been…
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