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creatol

Known as: 2-amino-5-hydroxy-1-methylimidazol-4(5H)-one, 5-hydroxycreatinine 
National Institutes of Health

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Creatinine
analogs & derivatives

Papers overview

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2011
2011
Serum accumulation of a creatinine oxidative metabolite (NZ-419: 5-hydroxy-1- methylhydatoin) as an intrinsic antioxidant in diabetic patients with or without chronic kidney disease.
AIMS In mammals, creatinine (Cr) is catabolized by a dual oxidative pathway via 5-hydroxy-1-methylhydantoin or 5… 
2007
2007
Urinary Excretion of Creatol, an In Vivo Biomarker of Hydroxyl Radical, in Patients with Chronic Renal Failure
Creatol (CTL) is a hydroxyl radical adduct of creatinine (Cr). The serum methylguanidine (MG) level and the MG/Cr molar ratio are… 
2000
2000
Creatol, an oxidative product of creatinine in hemodialysis patients
Creatol (CTL) is a product resulting from the reaction of creatinine (Cr) with the hydroxyl radical and is identified as a… 
1998
1998
Synthesis of creatol, a hydroxyl radical adduct of creatinine and its increase by puromycin aminonucleoside in isolated rat hepatocytes.
Creatol is a hydroxyl radical adduct of creatinine and the precursor of methylguanidine (MG), a uremic toxin. We investigate the… 
1997
1997
Changes in serum levels of creatol and methylguanidine in renal injury induced by lipid peroxide produced by vitamin E deficiency and GSH depletion in rats.
A novel creatinine metabolite, creatol (5-hydroxycreatinine), is a key precursor in the synthesis of the uremic toxin… 
1996
1996
Diabetic renal failure and serum accumulation of the creatinine oxidative metabolites creatol and methylguanidine.
Diabetic patients (n = 23) with chronic renal failure (CRF) accumulate the creatinine (Cr) oxidative metabolites creatol (CTL… 
1994
1994
Creatol, a creatinine metabolite, as a useful determinant of renal function.
Analysis of creatol (CTL, 5-hydroxycreatinine), an oxidative creatinine (Cr) metabolite, in serum and urine of human subjects has… 
1993
1993
Comparison of renal effects of creatinine, creatol and methylguanidine in rats with adenine-induced chronic renal failure.
Creatinine (Cr), creatol and methylguanidine (MG), which accumulate in the body with the progress of renal failure after adenine… 
1993
1993
Purification of methylguanidine synthase from the rat kidney.
Methylguanidine (MG)-synthesizing enzyme was purified from rat kidney lysosomes and peroxisomes. The enzyme was a flavoprotein… 
1990
1990
Creatol (5-hydroxycreatinine), a new toxin candidate in uremic patients
Both 5-hydroxy-1-methylhydantoin (3) and the hitherto unrecognized 5-hydroxycreatinine (2-amino-5-hydroxy-1-methyl-imidazol-4(5H… 
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