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Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry
TLDR
The liver and intestinal bacteria participate in the metabolism and disposition of Ber in vivo, and the intestinal flora played a significant role in the enterohepatic circulation of metabolites. Expand
Biotransformation of (-)-epicatechin 3-O-gallate by human intestinal bacteria.
TLDR
The biotransformation of (-)-epicatechin 3-O-gallate and related compounds was undertaken using a human fecal suspension, suggesting a difference in metabolic ability between two intestinal bacterial mixtures from different species. Expand
New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells.
TLDR
Three new lanostante-type triterpene aldehydes, named lucialdehydes A-C (1-3), were isolated from the fruiting bodies of Ganoderma lucidum and showed cytotoxic effects on tested tumor cells. Expand
Screening of various plant extracts used in ayurvedic medicine for inhibitory effects on human immunodeficiency virus type 1 (HIV‐1) protease
TLDR
One of them, arecatannin B1 showed significant HIV‐1‐PR inhibitory activity and was shown by the A. catechu extract, from which some procyanidins were isolated. Expand
Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum.
TLDR
A new highly oxygenated triterpene named ganoderic acid alpha has been isolated from a methanol extract of the fruiting bodies of Ganoderma lucidum together with twelve known compounds by spectroscopic means including 2D-NMR. Expand
Human intestinal bacteria capable of transforming secoisolariciresinol diglucoside to mammalian lignans, enterodiol and enterolactone.
TLDR
Seven metabolites were isolated after anaerobic incubation of secoisolariciresinol diglucoside with a human fecal suspension and two bacterial strains, Peptostreptococcus sp. Expand
Inhibition of human immunodeficiency virus type 1 reverse transcriptase and ribonuclease H activities by constituents of Juglans mandshurica.
TLDR
From the stem-bark of Juglans mandshurica, two new naphthalenyl glucopyranosides exhibited the most potent inhibition of reverse transcriptase (RT) activity, while the latter compound also inhibited ribonuclease H (RNase H) activity with an IC50 of 39 microM, comparable in potency to illimaquinone used as a positive control. Expand
Screening of Chinese and Mongolian herbal drugs for anti‐human immunodeficiency virus type 1 (HIV‐1) activity
TLDR
Water and methanol extracts of 30 Chinese and Mongolian medicinal plants were tested for their human immunodeficiency virus type‐1 (HIV‐1) inhibitory activity and led to the isolation of two alkaloids, aromoline and FK‐3000 as potent inhibitory substances. Expand
Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease.
TLDR
Two new lanostane-type triterpenes, lucidumol A and ganoderic acid beta, were isolated from the spores of Ganoderma (G.) lucidum and showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM. Expand
Inhibitory effects of Sudanese medicinal plant extracts on hepatitis C virus (HCV) protease
TLDR
Eight extracts, methanol extracts of Acacia nilotica, Boswellia carterii, Embelia schimperi, Quercus infectoria, Trachyspermum ammi and water extracts of Piper cubeba, Q. infectoria and Syzygium aromaticum were the most active. Expand
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