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codeine-6-glucuronide

Known as: beta-D-Glucopyranosiduronic acid, (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-yl 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Codeine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Pharmacokinetics of acetaminophen, codeine, and the codeine metabolites morphine and codeine-6-glucuronide in healthy Greyhound dogs.
  • B. Kukanich
  • Journal of veterinary pharmacology and…
  • 2010
    • Corpus ID: 20609
The purpose of this study was to determine the pharmacokinetics of codeine and the active metabolites morphine and codeine-6… Expand
Highly Cited
2006
Highly Cited
2006
Evidence for morphine‐independent central nervous opioid effects after administration of codeine: Contribution of other codeine metabolites
Our objective was to investigate whether codeine or one of its metabolites contributes substantially to central nervous effects… Expand
Highly Cited
2000
Highly Cited
2000
Codeine analgesia is due to codeine-6-glucuronide, not morphine.
Abstract Eighty per cent of codeine is conjugated with glucuronic acid to codeine-6-glucuronide. Only 5% of the dose is O… Expand
Highly Cited
1997
Highly Cited
1997
Determination of morphine and its 3- and 6-glucuronides, codeine, codeine-glucuronide and 6-monoacetylmorphine in body fluids by liquid chromatography atmospheric pressure chemical ionization mass…
A selective assay of morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G), morphine, codeine, codeine-6-glucuronide (C6G… Expand
Highly Cited
1997
Highly Cited
1997
Human UGT2B7 catalyzes morphine glucuronidation.
A human UDP-glucuronosyltransferase (UGT) catalyzing the glucuronidation of morphine has been identified. A full length cDNA was… Expand
Highly Cited
1992
Highly Cited
1992
Pharmacokinetics and metabolism of codeine in humans
Codeine (30 mg phosphate) was metabolized by eight human volunteers to the following six metabolites: codeine‐6‐glucuronide 81·0… Expand
Highly Cited
1991
Highly Cited
1991
Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquine.
1. The kinetics of codeine and seven of its metabolites codeine-6-glucuronide (C6G), norcodeine (NC), NC-glucuronide (NCG… Expand
Highly Cited
1991
Highly Cited
1991
Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers.
1. The pharmacokinetics, metabolism and partial clearances of codeine to morphine, norcodeine and codeine-6-glucuronide after… Expand
Highly Cited
1989
Highly Cited
1989
Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation.
1. A single oral dose of codeine (25 mg) was given to 132 healthy Swedish Caucasians who had previously been phenotyped with… Expand
Highly Cited
1989
Highly Cited
1989
Interindividual and interethnic differences in the demethylation and glucuronidation of codeine.
1. The 8 h urinary excretion of codeine and seven of its metabolites was compared in 149 healthy Swedish Caucasians and 133… Expand
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