T. Vree

Publications435
h-index41
Citations7,340
Highly Influential Citations164
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Pharmacokinetics of enterolignans in healthy men and women consuming a single dose of secoisolariciresinol diglucoside.
TLDR
The measured mean residence times and elimination half-lives indicate that enterolignans accumulate in plasma when consumed 2-3 times a day and reach steady state, and are expected to be good biomarkers of dietary lignan exposure and can be used to evaluate the effects of lignans.
Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans
TLDR
A rapid gas chromatographic assay method is described for PG and the plasma pharmacokinetics after intravenous administration to six patients on nine occasions, finding no evidence of lactic acidosis, hemolysis, or increase in osmolality at 3–15 g/m2 PG infused over periods of 4 h.
The influence of quinolone derivatives on theophylline clearance.
TLDR
There is growing evidence that the observed interaction is caused not by the parent drugs, but by the 4-oxo metabolite of enoxacin, pefloxac in and ciprofloxACin and nalidixic acid.
Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans.
TLDR
Quercetin glucosides are rapidly absorbed in humans, irrespective of the position of the glucose moiety, and conversion of querbetin glycosides into glucoside is a promising strategy to enhance bioavailability of quercet in foods.
Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs.
TLDR
The pharmacokinetics of ciprofloxacin, a quinoline derivative with marked bactericidal activity against gram-negative bacteria, was studied in calves and pigs following intravenous and oral administration and indicated a predominantly tubular secretion pattern.
Clinical pharmacokinetics of sulfonamides and their metabolites: an encyclopedia.
Pharmacokinetics of naproxen, its metabolite O‐desmethylnaproxen, and their acyl glucuronides in humans
The aim of this investigation was to assess the pharmacokinetics of naproxen in 10 human subjects after an oral dose of 500 mg using a direct HPLC analysis of the acyl glucuronide conjugates of…
Pharmacokinetics, metabolism, and renal excretion of articaine and its metabolite articainic acid in patients after epidural administration.
TLDR
Of the administered dose approximately 2-5% is excreted unchanged, 40-70% isexcreted as articainic acid, and 4-15% as articainsic acid glucoronide.
Pharmacokinetics and renal clearance of oxytetracycline in piglets following intravenous and oral administration.
TLDR
It is concluded that in piglets OTC is excreted mainly by glomerular filtration and partly by tubular secretion, being 3-5 times higher than the latter.
Pharmacokinetics and metabolism of codeine in humans
  • T. Vree, C. Wissen
  • Biology, Medicine
    Biopharmaceutics & drug disposition
  • 1 August 1992
TLDR
Two out of eight volunteers were unable to O‐dealkylate codeine into morphine and lack therefore the cytochrome P450 IID6 isoenzyme, which is 10 times higher than that of codeine.
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