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Pharmacokinetics of enterolignans in healthy men and women consuming a single dose of secoisolariciresinol diglucoside.
High concentrations of enterolignans in plasma are associated with a lower risk of acute coronary events. However, little is known about the absorption and excretion of enterolignans. The… Expand
Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans
Knowledge of the pharmacokinetics of propylene glycol (PG) is scarce, though it is used in a number of preparations for intravenous use. Although systemic toxicity appears to be uncommon, PG has been… Expand
Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs.
- J. Nouws, D. Mevius, T. Vree, A. Baars, J. Laurensen
- Biology, Medicine
- The Veterinary quarterly
- 1 July 1988
The pharmacokinetics of ciprofloxacin, a quinoline derivative with marked bactericidal activity against gram-negative bacteria, was studied in calves and pigs following intravenous and oral… Expand
Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans.
The flavonoid quercetin is an antioxidant which occurs in foods mainly as glycosides. The sugar moiety in quercetin glycosides affects their bioavailability in humans. Quercetin-3-rutinoside is an… Expand
Plasma and urinary excretion kinetics of oral baclofen in healthy subjects
- E. Wuis, M. Dirks, E. Termond, T. Vree, E. Kleijn
- European Journal of Clinical Pharmacology
SummaryBaclofen, a centrally acting muscle relaxant, is used in the treatment of spasticity. Its pharmacokinetics has been derived from plasma and urine data in four healthy subjects, whose renal… Expand
Clinical pharmacokinetics of sulfonamides and their metabolites: an encyclopedia.
The influence of quinolone derivatives on theophylline clearance.
- W. Wijnands, T. Vree, C. Van herwaarden
- British journal of clinical pharmacology
- 1 December 1986
Enoxacin decreases the metabolic clearance of the bronchodilator theophylline not only in severely ill patients, but also in patients with stable chronic obstructive airways disease. In this… Expand
Pharmacokinetics of naproxen, its metabolite O‐desmethylnaproxen, and their acyl glucuronides in humans
- T. Vree, M. van den Biggelaar-Martea, C. P. Verwey-van Wissen, J. B. Vree, P. Guelen
- Chemistry, Medicine
- Biopharmaceutics & drug disposition
- 1 August 1993
The aim of this investigation was to assess the pharmacokinetics of naproxen in 10 human subjects after an oral dose of 500 mg using a direct HPLC analysis of the acyl glucuronide conjugates of… Expand
Pharmacokinetics, metabolism, and renal excretion of articaine and its metabolite articainic acid in patients after epidural administration.
- G. E. van Oss, T. Vree, A. Baars, E. Termond, L. H. Booij
- European journal of anaesthesiology
Articaine is metabolized into articainic acid. The half-lives of articaine are 0.54 +/- 0.05 and 2.44 +/- 0.30 h and that of its metabolite, 2.44 +/- 0.30 h. Of the administered dose approximately… Expand
Pharmacokinetics and renal clearance of oxytetracycline in piglets following intravenous and oral administration.
- D. Mevius, L. Vellenga, H. Breukink, J. Nouws, T. Vree, F. Driessens
- The Veterinary quarterly
- 1 October 1986
The pharmacokinetics of oxytetracycline (OTC) in three weaned piglets was studied following three routes of administration: intravenously, orally as drench, both at a dose of 20 mg/kg, and orally as… Expand