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clofarabine

Known as: CAFdA, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arbinofuranosyl)adenine, 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine 
A second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Adenine NucleotidesAntimetabolites, AntineoplasticArabinonucleosides

Narrower (2)

ClolarEvoltra
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Hominin DNA baffles experts
Analysis of oldest sequence from a human ancestor suggests link to mystery population. 
2010
2010
A phase I/II trial of clofarabine in patients with relapsed T-cell or NK-cell lymphomas.
8046 Background: Peripheral T-cell lymphomas (PTCL) are a heterogeneous and poor prognostic subset of non-Hodgkin's lymphoma… 
2006
2006
The activity and toxicity of low dose clofarabine against relapsed or refractory myeloma.
Eight patients with refractory multiple myeloma were treated with clofarabine 4 mg/m2/day on days 1-5 of a 28 day cycle. No… 
2004
2004
Clofarabine. Treatment of acute leukemia
Clofarabine (Clofarex, 2-Cl-2'-F-araA, CAFdA) is a novel anticancer agent shown to be particularly effective in acute leukemia… 
1984
1984
Nucleoside conjugates V: Synthesis and biological activity of 9-(beta-D-arabinofuranosyl)adenine conjugates of corticosteroids.
Eight 5'-(steroid-21-phosphoryl)-9-(beta-D-arabinofuranosyl)-adenines (IV-XI) have been prepared and evaluated against L1210… 
1979
1979
Prodrugs of 9-(beta-D-arabinofuranosyl)adenine 2. Synthesis and evaluation of a number of 2',3'- and 3',5'-di-O-acyl derivatives.
A number of 2',3'- and 3',5'-di-O-acyl derivatives of 9-beta-D-arabinofuranosyladenine (1) were prepared and evaluated as… 
1977
1977
Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.
In order to evaluate the influence of the cyano group on the antiviral activity of pyrimidine deoxyribonucleosides, a moderate… 
1976
1976
Synthesis and anti-DNA -virus activity of the 5'-monophosphate and the cyclic 3',5'-monophosphate of 9-(beta-D-xylofuranosyl) guanine.
9-(beta-TD-xylofuranosyl)guanine (xylo-G) was converted chemically to the 9-(beta-D-xylofuranosyl)guanine 5'-monophosphate (xylo… 
1975
1975
Substrate specificity of ribosomal peptidyltransferase. Effect of modification in the heterocyclic, carbohydrate and amino acid moiety of 2'(3')-O-L-phenylalanyladenosine.
The chemical synthesis of 2'(3')-O-L-phenylalanyl derivatives of nebularine (Ld), 6-methoxynebularine (Ih), N6,N6… 
1967
1967
N-oxides of 9-(beta-D-xylofuranosyl)adenine and 9-(beta-D-arabinofuranosyl)adenine.