clofarabine

Known as: CAFdA, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arbinofuranosyl)adenine, 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine 
A second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
PURPOSE To compare the receipt of clofarabine plus cytarabine (Clo+Ara-C arm) with cytarabine (Ara-C arm) in patients ≥ 55 years… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE To assess the toxicity, pharmacokinetics, and pharmacodynamics of multikinase inhibitor sorafenib in combination with… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE This phase II study assessed clofarabine monotherapy in older adults (>or= 60 years of age) with untreated acute myeloid… (More)
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Highly Cited
2008
Highly Cited
2008
We previously reported the feasibility of clofarabine and cytarabine combinations in AML. Questions remain as to (1) the… (More)
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Highly Cited
2004
Highly Cited
2004
Clofarabine (2-chloro-2'-fluoro-deoxy-9-beta-D-arabinofuranosyladenine) is a second-generation nucleoside analog with activity in… (More)
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2004
2004
Clofarabine has proven to be effective in the treatment of adult and pediatric acute myelogenous leukemia (AML). To investigate… (More)
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Highly Cited
2003
Highly Cited
2003
In a phase 2 study, 62 patients with relapsed and refractory acute myeloid leukemia (AML; n = 31), myelodysplastic syndrome (MDS… (More)
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Highly Cited
2003
Highly Cited
2003
Despite progress in leukemia therapy, most children who experience relapse have a dismal prognosis. New, effective approaches are… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE To define the maximum-tolerated doses (MTDs) and dose-limiting toxicities (DLTs) of clofarabine, given as a 1-hour… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE Chronic lymphocytic leukemia (CLL) lymphocytes respond to DNA alkylation by excision repair, with the extent of repair… (More)
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