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clofarabine

Known as: CAFdA, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arbinofuranosyl)adenine, 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine 
A second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Adenine NucleotidesAntimetabolites, AntineoplasticArabinonucleosides

Narrower (2)

ClolarEvoltra
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Long-Term Follow-Up and Impact of Comorbidity before Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Relapsed or Refractory Acute Myeloid Leukemia-Lessons Learned from the…
2014
2014
The development of a myeloablative, reduced-toxicity, conditioning regimen for cord blood transplantation.
2012
2012
Cytoreductive treatment with clofarabine/ara‐C combined with reduced‐intensity conditioning and allogeneic stem cell transplantation in patients with high‐risk, relapsed, or refractory acute myeloid…
The combination of cytoreductive chemotherapy with reduced‐intensity conditioning (RIC) is a highly effective antileukemic… 
2012
2012
Clofarabine, cyclophosphamide and etoposide for the treatment of relapsed or resistant acute leukemia in pediatric patients
Abstract Clofarabine is a promising new chemotherapeutic agent that is active in the treatment of pediatric acute leukemia. Forty… 
2009
2009
Successful induction therapy with decitabine in refractory childhood acute lymphoblastic leukemia
Successful induction therapy with decitabine in refractory childhood acute lymphoblastic leukemia 
Review
2009
Review
2009
Clofarabine as a novel nucleoside analogue approved to treat patients with haematological malignancies: mechanism of action and clinical activity.
Clofarabine is a second generation of purine nucleoside analogues designed to combine the most favorable pharmacokinetic… 
2006
2006
A phase II study (Biov-121) of clofarabine monotherapy first line in patients aged 65 years or older with acute myeloid leukemia for whom standard intensive chemotherapy is not considered suitable.
Background: The treatment of older patients with AML is unsatisfactory and not improving. A substantial proportion of patients… 
1999
1999
Distribution of 2-chloro-2′-deoxyadenosine, 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine, Fludarabine and Cytarabine in mice: a whole-body autoradiography study
The distribution characteristics of tritiated nucleoside analogs, 2-chloro-2′-deoxyadeonosine (CdA), 2-chloro-2′-arabino-fluoro-2… 
1998
1998
Analysis of DNA methylation of the 5' region of the deoxycytidine kinase gene in CCRF-CEM-sensitive and cladribine (CdA)- and 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine (CAFdA)-resistant cells.
1979
1979
Prodrugs of 9-(beta-D-arabinofuranosyl)adenine 2. Synthesis and evaluation of a number of 2',3'- and 3',5'-di-O-acyl derivatives.
A number of 2',3'- and 3',5'-di-O-acyl derivatives of 9-beta-D-arabinofuranosyladenine (1) were prepared and evaluated as… 
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