clazosentan

Known as: N-(6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-(1H-tetrazol-5-yl)pyridin-4-yl)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide, N-{6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-(1H-tetrazol-5-yl)pyridin-4-yl)pyrimidin-4-yl}-5-methylpyridine-2-sulfonamide 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2018
051020042018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
We report here results of a randomized, double-blind, placebo-controlled study ( http://www.ClinicalTrials.gov… (More)
Is this relevant?
2012
2012
BACKGROUND AND PURPOSE Clazosentan, an endothelin receptor antagonist, has been shown to reduce vasospasm after aneurysmal… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
2012
2012
BACKGROUND Cerebral vasospasm is the most important potentially treatable cause of mortality and morbidity following aneurysmal… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2011
Highly Cited
2011
BACKGROUND Clazosentan, an endothelin receptor antagonist, significantly and dose-dependently reduced angiographic vasospasm… (More)
Is this relevant?
2011
2011
BACKGROUND AND PURPOSE Endothelin receptor antagonists such as clazosentan decrease large-artery vasospasm after experimental and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2011
2011
One of the major complications after subarachnoid hemorrhage (SAH) is angiographic vasospasm in the large arteries at the base of… (More)
Is this relevant?
2008
2008
Clazosentan (Ro 61-1790, VML-588 or AXV-034) is under study in clinical trials for the treatment of patients with aneurysmal… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
IL-33, a new member of the IL-1 family, signals through its receptor ST2 and induces T helper 2 (Th2) cytokine synthesis and… (More)
Is this relevant?
2006
2006
The purpose of this study was to investigate in healthy male subjects the tolerability, pharmacokinetics, and pharmacodynamics of… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?
Highly Cited
2005
Highly Cited
2005
OBJECTIVE The goal of this study was to investigate the safety and tolerability of the novel endothelin A (ETA) receptor… (More)
Is this relevant?