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cipargamin

 
National Institutes of Health

Papers overview

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2019
2019
Highly enantioselective rhodium-catalyzed addition of arylboroxines to N-unprotected ketimines are realized for the first time by… Expand
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2019
2019
The Plasmodium falciparum ATPase PfATP4 is the target of a diverse range of antimalarial compounds, including the clinical drug… Expand
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2018
2018
For an increasing number of antimalarial agents identified in high-throughput phenotypic screens, there is evidence that they… Expand
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2018
2018
The antimalarial activity of chemically diverse compounds, including the clinical candidate cipargamin, has been linked to the… Expand
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2017
2017
The MIC of an antimalarial drug for a particular infection is the drug level associated with a net parasite multiplication rate… Expand
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2016
2016
The spiroindolones, a new class of antimalarial medicines discovered in a cellular screen, are rendered less active by mutations… Expand
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2016
2016
KAE609 [(1'R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyridol[3,4-b]indol]-2-one] is a… Expand
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2015
2015
KAE609 represents a new class of potent, fast-acting, schizonticidal antimalarials. This study investigated the safety and… Expand
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2015
2015
I diseases remain a significant cause of morbidity and mortality, among which tuberculosis (TB) and malaria are among the biggest… Expand
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2014
2014
This first-in-human randomized, double-blind, placebo-controlled, ascending-single and -multiple oral dose study was designed to… Expand
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