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Factors related to errors in medication prescribing.
TLDR
By improving the focus of organizational, technological, and risk management educational and training efforts using the factors commonly associated with prescribing errors, risk to patients from adverse drug events should be reduced.
CD4+ lymphocyte cell enumeration for prediction of clinical course of human immunodeficiency virus disease: a review.
TLDR
It is of paramount importance that clinicians be cognizant of and fully understand the multiple factors that can influence this parameter: the variability of the count from day to day and from morning to night, the influence of intercurrent viral infections, the Influence of drugs.
Within-subject variation in CD4 lymphocyte count in asymptomatic human immunodeficiency virus infection: implications for patient monitoring.
TLDR
CD4 cell counts from 1020 untreated subjects with asymptomatic HIV infection monitored by standardized methods for up to 2 years were assessed; declines were greater in HIV p24-positive subjects and those with higher lymphocyte percentages or lower platelet counts or hemoglobin levels.
Pharmacokinetics of zidovudine phosphorylation in peripheral blood mononuclear cells from patients infected with human immunodeficiency virus
TLDR
Metabolism of ZDV to its active intracellular forms may be saturable in some patients, is poorly correlated with plasma concentrations, and diminishes over time, suggesting that an every-8-h dosing regimen is justifiable.
A 24-week open-label Phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir)
TLDR
MK-639 appears to have significant dose-related antiviral activity and is well tolerated and the return of CD4 cells being strongly related to the number ofCD4 cells at baseline with a sigmoid-Emax relationship.
Phase I/II evaluation of nevirapine alone and in combination with zidovudine for infection with human immunodeficiency virus.
TLDR
This study demonstrates a direct relationship between drug resistance and effects on surrogate markers in HIV-1 infection and shows early suppression of p24 antigen levels and increase in CD4+ cell count were reversed following rapid emergence of virus less susceptible to nevirapine.
Phosphorylation of Nucleoside Analog Antiretrovirals: A Review for Clinicians
TLDR
In vitro and in vivo studies give important insights into mechanisms of action, metabolic feedback mechanisms, antiviral effects, and mechanisms of toxicity, and have influenced dosing regimens of nucleoside analogs.
Pharmacokinetics of [14C]Abacavir, a Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitor, Administered in a Single Oral Dose to HIV-1-Infected Adults: a Mass Balance Study
TLDR
The main route of elimination for oral abacavir in humans is metabolism, with <2% of a dose recovered in urine as unchanged drug.
Pharmacokinetic and Pharmacodynamic Study of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir after Multiple Oral Dosing
TLDR
The pharmacodynamic relationship defined in this study supports the use of 1,200 mg b.i.d. as the approved dose of amprenavir, an inhibitor of the protease enzyme of human immunodeficiency virus (HIV) type 1.
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