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Factors related to errors in medication prescribing.
OBJECTIVE To quantify the type and frequency of identifiable factors associated with medication prescribing errors. DESIGN AND SETTING Systematic evaluation of every third prescribing error… Expand
Comparative Study of the Effects of a 1-Year Dietary Intervention of a Low-Carbohydrate Diet Versus a Low-Fat Diet on Weight and Glycemic Control in Type 2 Diabetes
OBJECTIVE To compare the effects of a 1-year intervention with a low-carbohydrate and a low-fat diet on weight loss and glycemic control in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS… Expand
CD4+ lymphocyte cell enumeration for prediction of clinical course of human immunodeficiency virus disease: a review.
Over the last 10 years the appreciation of the full breadth of the spectrum of human immunodeficiency virus (HIV) infection has gradually increased; it is now known that AIDS represents merely the… Expand
Within-subject variation in CD4 lymphocyte count in asymptomatic human immunodeficiency virus infection: implications for patient monitoring.
- M. Hughes, D. Stein, H. Gundacker, F. Valentine, J. Phair, P. Volberding
- The Journal of infectious diseases
Changes in CD4 lymphocyte counts are widely used in monitoring human immunodeficiency virus (HIV)-infected patients for disease progression. However, random fluctuations may obscure clinically… Expand
Phase I/II evaluation of nevirapine alone and in combination with zidovudine for infection with human immunodeficiency virus.
- S. Cheeseman, D. Havlir, +7 authors M. Myers
- Journal of acquired immune deficiency syndromes…
- 1 February 1995
In these Phase I/II open-label clinical trials, 62 persons with human immunodeficiency virus type 1 (HIV-1) infection and CD4+ cell counts < 400/mm3 received nevirapine at doses of 12.5, 50, and 200… Expand
Clinical disposition, metabolism and in vitro drug–drug interaction properties of omadacycline
- J. Flarakos, Y. Du, +16 authors J. Mangold
- Biology, Medicine
- Xenobiotica; the fate of foreign compounds in…
- 1 August 2017
Abstract 1. Absorption, distribution, metabolism, transport and elimination properties of omadacycline, an aminomethylcycline antibiotic, were investigated in vitro and in a study in healthy male… Expand
A 24-week open-label Phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir)
Objective:To investigate the safety, pharmacokinetics, and activity of the orally bioavailable protease inhibitor MK-639. Design:An open-label Phase I/II trial of medically stable subjects with… Expand
Combination and Monotherapy with Zidovudine and Zalcitabine in Patients with Advanced HIV Disease
Several nucleoside analogs, including zidovudine, zalcitabine, and didanosine, inhibit the replication of human immunodeficiency virus type 1 (HIV) in vitro and improve CD4 cell counts and suppress… Expand
Pharmacokinetics of zidovudine phosphorylation in peripheral blood mononuclear cells from patients infected with human immunodeficiency virus.
- B. N. Stretcher, A. Pesce, P. T. Frame, D. Stein
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 July 1994
As part of an effort towards optimization of dosing of zidovudine (ZDV), formation and elimination of total phosphorylated ZDV (ZDVPt) in peripheral blood mononuclear cells were examined in 21… Expand
Phosphorylation of Nucleoside Analog Antiretrovirals: A Review for Clinicians
Nucleoside analogs (zidovudine, didanosine, zalcitabine, stavudine, abacavir, lamivudine) have been administered as antiretroviral agents for more than a decade. They undergo anabolic phosphorylation… Expand