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Malaria is caused by the Plasmodium parasite and is a major health problem leading to many deaths worldwide. Lack of a vaccine… Expand An asymmetric aza-Diels-Alder reaction of 3-vinylindoles with isatin-derived ketimines has been developed. A series of… Expand A direct catalytic asymmetric alkynylation protocol is applied to provide the requisite enantioenriched propargylic α-tertiary… Expand ABSTRACT This first-in-human randomized, double-blind, placebo-controlled, ascending-single and -multiple oral dose study was… Expand ABSTRACT To achieve malarial elimination, we must employ interventions that reduce the exposure of human populations to… Expand ABSTRACT Here, we show that spiroindolone, an effective treatment for plasmodia, is also active against Toxoplasma gondii… Expand The need for new drugs against tropical parasites such as Plasmodium falciparum and Trypanosoma brucei is persistent since… Expand ABSTRACT The global malaria agenda has undergone a reorientation from control of clinical cases to entirely eradicating malaria… Expand During the synthesis of the new antimalarial drug candidate NITD609, a high degree of diastereoselectivity was observed in the… Expand A return to traditional screening methods has rapidly produced a candidate malaria drug. Every so often, the tide turns in a… Expand