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cicaprost

Known as: 13,14-didehydro-16,20-dimethyl-3-oxa-18,18,19,19-tetradehydro-6-carbaprostaglandin I2, 5-(7-hydroxy-6-(3-hydroxy-4-methylnona-1,6-diynyl)-bicyclo(3.3.0)octan-3-yliden)-3-oxapentanoic acid 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Antineoplastic AgentsEpoprostenol

Narrower (1)

ZK 96480
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Agonist-dependent internalization and trafficking of the human prostacyclin receptor: A direct role for Rab5a GTPase
2004
2004
Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase.
Long-term infusion of prostacyclin, or its analogs, is an effective treatment for severe pulmonary arterial hypertension. However… 
Highly Cited
2004
Highly Cited
2004
Dimerization of the Human Receptors for Prostacyclin and Thromboxane Facilitates Thromboxane Receptor-mediated cAMP Generation*
Prostacyclin (PGI2) and thromboxane (TxA2) are biological opposites; PGI2, a vasodilator and inhibitor of platelet aggregation… 
2003
2003
Protein kinase A-dependent coupling of mouse prostacyclin receptors to Gi is cell-type dependent.
2003
2003
Asymmetric synthesis of the highly potent anti-metastatic prostacyclin analogue cicaprost and its isomer isocicaprost.
An asymmetric synthesis of the anti-metastatic prostacyclin analogue cicaprost and a formal one of its isomer isocicaprost by a… 
2002
2002
Actions of prostanoids to induce emesis and defecation in the ferret.
Highly Cited
1999
Highly Cited
1999
Prostanoid receptors involved in the relaxation of human pulmonary vessels
To characterize the prostanoid receptors on human pulmonary smooth muscle involved in vasodilatations, isolated arteries and… 
Highly Cited
1995
Highly Cited
1995
Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids
We investigated cooperative effects of phosphodiesterase (PDE) inhibitors and prostanoids on cyclic adenosine monophosphate (cAMP… 
Highly Cited
1994
Highly Cited
1994
Potent contractile actions of prostanoid EP3‐receptor agonists on human isolated pulmonary artery
1 In 13 of 15 experiments, prostaglandin E2 (PGE2) and sulprostone (a prostanoid EP1/EP3‐receptor agonist) contracted isolated… 
1993
1993
Arachidonic acid stimulates interleukin-6 release from rat peritoneal macrophages in vitro: evidence for a prostacyclin-dependent mechanism.
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