Skip to search formSkip to main contentSkip to account menu

cicaprost

Known as: 13,14-didehydro-16,20-dimethyl-3-oxa-18,18,19,19-tetradehydro-6-carbaprostaglandin I2, 5-(7-hydroxy-6-(3-hydroxy-4-methylnona-1,6-diynyl)-bicyclo(3.3.0)octan-3-yliden)-3-oxapentanoic acid 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Antineoplastic AgentsEpoprostenol

Narrower (1)

ZK 96480
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Agonist-dependent internalization and trafficking of the human prostacyclin receptor: A direct role for Rab5a GTPase
2006
2006
Lack of interaction between prostaglandin E2 receptor subtypes in regulating adenylyl cyclase activity in cultured rat dorsal root ganglion cells.
2004
2004
Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase.
Long-term infusion of prostacyclin, or its analogs, is an effective treatment for severe pulmonary arterial hypertension. However… 
Highly Cited
2004
Highly Cited
2004
Dimerization of the Human Receptors for Prostacyclin and Thromboxane Facilitates Thromboxane Receptor-mediated cAMP Generation*
Prostacyclin (PGI2) and thromboxane (TxA2) are biological opposites; PGI2, a vasodilator and inhibitor of platelet aggregation… 
2003
2003
Asymmetric synthesis of the highly potent anti-metastatic prostacyclin analogue cicaprost and its isomer isocicaprost.
An asymmetric synthesis of the anti-metastatic prostacyclin analogue cicaprost and a formal one of its isomer isocicaprost by a… 
2001
2001
Role of endogenous prostacyclin in gastric ulcerogenic and healing responses—a study using IP-receptor knockout mice
1997
1997
Inhibition of metastasis by cicaprost in rats with established SMT2A mammary carcinoma growth.
Cicaprost, a stable prostacyclin analog has been shown to be antimetastatically active in a series of metastasizing rodent tumors… 
1996
1996
The inhibitory effects of non-prostanoid prostacyclin mimetics on rat neutrophil function.
Highly Cited
1994
Highly Cited
1994
Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.
BACKGROUND Prostacyclin elicits a potent vasodilation and inhibition of platelet aggregation through binding to its membrane… 
1993
1993
Arachidonic acid stimulates interleukin-6 release from rat peritoneal macrophages in vitro: evidence for a prostacyclin-dependent mechanism.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)