cicaprost

Known as: 13,14-didehydro-16,20-dimethyl-3-oxa-18,18,19,19-tetradehydro-6-carbaprostaglandin I2, 5-(7-hydroxy-6-(3-hydroxy-4-methylnona-1,6-diynyl)-bicyclo(3.3.0)octan-3-yliden)-3-oxapentanoic acid 
 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Antineoplastic AgentsEpoprostenol

Narrower (1)

ZK 96480
analogs & derivatives

Papers overview

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Highly Cited
2007
Highly Cited
2007
Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells.
Signaling through the PGI(2) receptor (IP) has been shown to inhibit inflammatory responses in mouse models of respiratory… (More)
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2006
2006
Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism.
OBJECTIVE We investigated the role of the inward rectifier potassium (KIR) channel and the cyclic AMP-dependent pathway in… (More)
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Highly Cited
2002
Highly Cited
2002
ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells.
We determined the distribution of ET(A) and ET(B) receptors in pulmonary arteries from pulmonary hypertensive patients and… (More)
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1999
1999
Prostanoid receptors involved in the relaxation of human pulmonary vessels.
1. To characterize the prostanoid receptors on human pulmonary smooth muscle involved in vasodilatations, isolated arteries and… (More)
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Highly Cited
1998
Highly Cited
1998
Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production.
Interleukin-10 (IL-10) and tumor necrosis factor (TNF) exert key roles in some acute and chronic inflammatory diseases. In this… (More)
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1997
1997
Effects of cicaprost and fosinopril on the progression of rat diabetic nephropathy.
We have studied the effects of chronic therapy with cicaprost (a PGI2 analog), fosinopril (a converting enzyme inhibitor), and… (More)
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1993
1993
A randomised, double-blind study of cicaprost, an oral prostacyclin analogue, in the treatment of Raynaud's phenomenon secondary to systemic sclerosis.
Cicaprost is a new synthetic prostacylin analogue which is metabolically stable and bioavailable after oral administration; in… (More)
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1993
1993
Cicaprost does not affect tumor inhibitory potential of cytostatic drugs.
Cicaprost, a stable prostacyclin analogue with antimetastatic potential, was investigated as regards its effect on the tumor… (More)
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1992
1992
Pharmacokinetics of iloprost and cicaprost in mice.
Iloprost and cicaprost are two PGI2-mimetics, which are chemically stable and highly pharmacologically potent. Both compounds… (More)
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1989
1989
Pharmacokinetics of 3H-cicaprost in healthy volunteers.
Cicaprost (5-[(E)-(1S,5S,6S,7R)-7-hydroxy-6-[(3S,4S)-3-hydroxy-4-methylnona- 1,6- diinyl]-bicyclo[3.3.0]octan-3-yliden]-3… (More)
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