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Epoprostenol

Known as: PGI2, PGX, Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)- 
An oral prostacyclin and a metabolite of arachidonic acid with antihypertensive and platelet inhibitory properties. Epoprostenol binds to… 
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (32)

10,10-difluoro-13-dehydroprostacyclin13,14-dehydroprostaglandin I213,14-dinor-inter-p-phenylene carbacyclin15-fluoro-13,14-dehydrocarbacyclin
Congestive heart failureEpoprostenol 1.5 MG InjectionEpoprostenol 1.5 MG Injection [Flolan]Epoprostenol Sodium

Broader (2)

Platelet Aggregation InhibitorsProstaglandins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1989
Highly Cited
1989
On the mechanism of prostacyclin and thromboxane A2 biosynthesis.
The present research describes studies which address the mechanism of prostacyclin (PGI2) and thromboxane A2 (TXA2) biosynthesis… 
Highly Cited
1985
Highly Cited
1985
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.
Highly Cited
1984
Highly Cited
1984
The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin.
The biochemical events underlying the ability of thrombin to enhance the metabolism of inositol phospholipids in human platelets… 
Highly Cited
1979
Highly Cited
1979
Decreased vascular prostacyclin in juvenile-onset diabetes.
Highly Cited
1979
Highly Cited
1979
Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin.
Highly Cited
1979
Highly Cited
1979
Peroxidase-dependent deactivation of prostacyclin synthetase.
A study of the enzymes of the arachidonic acid cascade revealed a high sensitivity of prostacyclin synthetase and a complete… 
Highly Cited
1978
Highly Cited
1978
Prostacyclin and thromboxane A2 biosynthesis capacities of heart, arteries and platelets at various stages of experimental atherosclerosis in rabbits.
Highly Cited
1978
Highly Cited
1978
Decreased vascular prostacyclin in experimental diabetes.
Highly Cited
1978
Highly Cited
1978
Enzymatic conversion of prostaglandin endoperoxide H2 and arachidonic acid to prostacyclin by cultured human endothelial cells.
Highly Cited
1977
Highly Cited
1977
Cyclic adenosine 3',5'-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets.
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