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Epoprostenol

Known as: PGI2, PGX, Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)- 
An oral prostacyclin and a metabolite of arachidonic acid with antihypertensive and platelet inhibitory properties. Epoprostenol binds to… Expand
National Institutes of Health

Papers overview

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Review
2009
Review
2009
The vascular inflammatory response involves complex interaction between inflammatory cells (neutrophils, lymphocytes, monocytes… Expand
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Highly Cited
2004
Highly Cited
2004
The efficacy and safety of combining bosentan, an orally active dual endothelin receptor antagonist and epoprostenol, a… Expand
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Highly Cited
2002
Highly Cited
2002
OBJECTIVES We sought to determine the factors associated with long-term survival in patients with primary pulmonary hypertension… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Primary pulmonary hypertension (PPH) is a severe and progressive disease. Without treatment, the median survival is 2… Expand
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Review
2002
Review
2002
The peroxisome proliferator-activated receptors (PPARs) are a group of three nuclear receptor isoforms, PPAR gamma, PPAR alpha… Expand
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Highly Cited
1997
Highly Cited
1997
This trial evaluated the effects of epoprostenol on patients with severe left ventricular failure. Patients with class IIIB/IV… Expand
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Primary pulmonary hypertension is a progressive disease for which no treatment has been shown in a prospective… Expand
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Highly Cited
1995
Highly Cited
1995
BACKGROUND Experimental evidence suggests that flow-dependent dilatation of conduit arteries is mediated by nitric oxide (NO) and… Expand
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Highly Cited
1990
Highly Cited
1990
STUDY OBJECTIVE To determine the efficacy of continuous intravenous infusion of prostacyclin (epoprostenol) in primary pulmonary… Expand
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Review
1985
Review
1985
  • S. T. Moore
  • Metabolism: clinical and experimental
  • 1985
  • Corpus ID: 2131191
There is abundant evidence that changes in diet and various types of vessel wall injury can independently induce the growth of… Expand
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