Epoprostenol

Known as: PGI2, PGX, Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)- 
An oral prostacyclin and a metabolite of arachidonic acid with antihypertensive and platelet inhibitory properties. Epoprostenol binds to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1936-2017
020040060019362016

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
BACKGROUND Oral sildenafil and intravenous epoprostenol have independently been shown to be effective in patients with pulmonary… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
Highly Cited
2004
Highly Cited
2004
The efficacy and safety of combining bosentan, an orally active dual endothelin receptor antagonist and epoprostenol, a… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
Highly Cited
2002
Highly Cited
2002
BACKGROUND Primary pulmonary hypertension (PPH) is a severe and progressive disease. Without treatment, the median survival is 2… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2002
Highly Cited
2002
OBJECTIVES We sought to determine the factors associated with long-term survival in patients with primary pulmonary hypertension… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
  • table 3
Is this relevant?
Highly Cited
2000
Highly Cited
2000
BACKGROUND Pulmonary hypertension is a progressive and often fatal complication of the scleroderma spectrum of disease for which… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
BACKGROUND Primary (idiopathic) pulmonary hypertension is a progressive, fatal disease. Conventional therapy with anticoagulant… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
This trial evaluated the effects of epoprostenol on patients with severe left ventricular failure. Patients with class IIIB/IV… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
BACKGROUND Primary pulmonary hypertension is a progressive disease for which no treatment has been shown in a prospective… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
BACKGROUND Experimental evidence suggests that flow-dependent dilatation of conduit arteries is mediated by nitric oxide (NO) and… (More)
Is this relevant?
Highly Cited
1976
Highly Cited
1976
Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that… (More)
Is this relevant?