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chymase activity

OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa. [EC:3.4.21.39]
National Institutes of Health

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Chymase

Papers overview

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Highly Cited
2017
Highly Cited
2017
Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure.
BACKGROUND The renin-angiotensin system (RAS) is activated in heart failure (HF) and inhibition of RAS is a mainstay therapy for… Expand
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2009
2009
Chymase activity is closely related with plaque vulnerability in a hamster model of atherosclerosis.
OBJECTIVE To test the hypothesis that stimulation of chymase secretion may contribute to plaque vulnerability and inhibition of… Expand
2008
2008
Role of Chymase-Dependent Matrix Metalloproteinase-9 Activation in Mice with Dextran Sodium Sulfate-Induced Colitis
Matrix metalloproteinase (MMP)-9 plays an important role in the pathogenesis of colitis. Recent studies have demonstrated that… Expand
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2008
2008
Cleaved SLPI, a novel biomarker of chymase activity
Abstract Secretory leukocyte protease inhibitor (SLPI) is a protease inhibitor of the whey acidic protein-like family inhibiting… Expand
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2005
2005
Angiotensin converting enzyme-independent angiotensin ii production by chymase is up-regulated in the ischemic kidney in renovascular hypertension.
BACKGROUND Tissue angiotensin II (ANG II) levels are elevated in both kidneys in renovascular hypertension (RVH). It has been… Expand
Highly Cited
2003
Highly Cited
2003
Impact of chymase inhibitor on cardiac function and survival after myocardial infarction.
OBJECTIVES Recent studies have demonstrated that hamsters, like humans, possess both angiotensin converting enzyme (ACE)- and… Expand
Highly Cited
2003
Highly Cited
2003
A Novel Chymase Inhibitor, 4-[1-{[bis-(4-Methyl-phenyl)-methyl]-carbamoyl}-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), Suppressed Cardiac Fibrosis in Cardiomyopathic Hamsters
Previously, we reported that levels of chymase activity and its mRNA in cardiac tissues were significantly increased along with… Expand
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2003
2003
Chymase: a potential culprit in diabetic nephropathy?
  • E. Ritz
  • Journal of the American Society of Nephrology…
  • 2003
    • Corpus ID: 37629921
In this issue of JASN , Huang et al. ([1][1]) report an immunohistochemical study in patients with diabetic nephropathy. While… Expand
2001
2001
Release of soluble tryptase but only minor amounts of chymase activity from cutaneous mast cells
Abstract: Tryptase and chymase are the major serine proteinases of skin mast cells but their biologic significance depends on… Expand
Highly Cited
1999
Highly Cited
1999
Mechanism by which heparin proteoglycan modulates mast cell chymase activity.
Chymases are highly basic chymotrypsin-like serine proteases expressed exclusively by mast cells. Large amounts of chymases… Expand
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