chymase activity

BACKGROUND The renin-angiotensin system (RAS) is activated in heart failure (HF) and inhibition of RAS is a mainstay therapy for… Expand

OBJECTIVE To test the hypothesis that stimulation of chymase secretion may contribute to plaque vulnerability and inhibition of… Expand

BACKGROUND Secretory leucocyte protease inhibitor (SLPI), which is present in many physiological fluids including saliva, sputum… Expand

Matrix metalloproteinase (MMP)-9 plays an important role in the pathogenesis of colitis. Recent studies have demonstrated that… Expand

Abstract Secretory leukocyte protease inhibitor (SLPI) is a protease inhibitor of the whey acidic protein-like family inhibiting… Expand

BACKGROUND Tissue angiotensin II (ANG II) levels are elevated in both kidneys in renovascular hypertension (RVH). It has been… Expand

OBJECTIVES Recent studies have demonstrated that hamsters, like humans, possess both angiotensin converting enzyme (ACE)- and… Expand

Previously, we reported that levels of chymase activity and its mRNA in cardiac tissues were significantly increased along with… Expand

In this issue of JASN , Huang et al. ([1][1]) report an immunohistochemical study in patients with diabetic nephropathy. While… Expand

Chymases are highly basic chymotrypsin-like serine proteases expressed exclusively by mast cells. Large amounts of chymases… Expand