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The renin-angiotensin system (RAS) is activated in heart failure (HF) and inhibition of RAS is a mainstay therapy for… Expand OBJECTIVE
To test the hypothesis that stimulation of chymase secretion may contribute to plaque vulnerability and inhibition of… Expand Matrix metalloproteinase (MMP)-9 plays an important role in the pathogenesis of colitis. Recent studies have demonstrated that… Expand Abstract Secretory leukocyte protease inhibitor (SLPI) is a protease inhibitor of the whey acidic protein-like family inhibiting… Expand BACKGROUND
Tissue angiotensin II (ANG II) levels are elevated in both kidneys in renovascular hypertension (RVH). It has been… Expand OBJECTIVES
Recent studies have demonstrated that hamsters, like humans, possess both angiotensin converting enzyme (ACE)- and… Expand Previously, we reported that levels of chymase activity and its mRNA in cardiac tissues were significantly increased along with… Expand In this issue of JASN , Huang et al. () report an immunohistochemical study in patients with diabetic nephropathy. While… Expand Abstract: Tryptase and chymase are the major serine proteinases of skin mast cells but their biologic significance depends on… Expand Chymases are highly basic chymotrypsin-like serine proteases expressed exclusively by mast cells. Large amounts of chymases… Expand