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chymase activity

OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa. [EC:3.4.21.39]
National Institutes of Health

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Chymase

Papers overview

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Highly Cited
2017
Highly Cited
2017
Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure.
Highly Cited
2008
Highly Cited
2008
Role of Chymase-Dependent Matrix Metalloproteinase-9 Activation in Mice with Dextran Sodium Sulfate-Induced Colitis
Matrix metalloproteinase (MMP)-9 plays an important role in the pathogenesis of colitis. Recent studies have demonstrated that… 
2008
2008
Cleaved SLPI, a novel biomarker of chymase activity
Abstract Secretory leukocyte protease inhibitor (SLPI) is a protease inhibitor of the whey acidic protein-like family inhibiting… 
2007
2007
Attenuating Effects of Chymase Inhibitor on Pericardial Adhesion Following Cardiac Surgery
Abstract  Objective: Chymase, a serine protease, is released from mast cells, which is closely associated with adhesion formation… 
2005
2005
Angiotensin converting enzyme-independent angiotensin ii production by chymase is up-regulated in the ischemic kidney in renovascular hypertension.
Highly Cited
2003
Highly Cited
2003
Impact of chymase inhibitor on cardiac function and survival after myocardial infarction.
Highly Cited
2003
Highly Cited
2003
A Novel Chymase Inhibitor, 4-[1-{[bis-(4-Methyl-phenyl)-methyl]-carbamoyl}-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), Suppressed Cardiac Fibrosis in Cardiomyopathic Hamsters
Previously, we reported that levels of chymase activity and its mRNA in cardiac tissues were significantly increased along with… 
2003
2003
Chymase: a potential culprit in diabetic nephropathy?
  • E. Ritz
  • Journal of the American Society of Nephrology…
  • 2003
  • Corpus ID: 37629921
In this issue of JASN , Huang et al. ([1][1]) report an immunohistochemical study in patients with diabetic nephropathy. While… 
Review
2001
Review
2001
Local angiotensin II-generating system in vascular tissues: the roles of chymase.
Roles of each angiotensin II producing enzymes of each of the angiotensin II-producing enzymes were reviewed based on… 
Highly Cited
1999
Highly Cited
1999
Mechanism by which heparin proteoglycan modulates mast cell chymase activity.
Chymases are highly basic chymotrypsin-like serine proteases expressed exclusively by mast cells. Large amounts of chymases… 
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