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Angiotensin-converting enzyme 2 is an essential regulator of heart function
Cardiovascular diseases are predicted to be the most common cause of death worldwide by 2020. Here we show that angiotensin-converting enzyme 2 (ace2) maps to a defined quantitative trait locus (QTL)… Expand
Counterregulatory actions of angiotensin-(1-7).
Angiotensin (Ang)-(1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. The first actions described for Ang-(1-7) indicated that the… Expand
COVID-19, ACE2, and the cardiovascular consequences
The novel SARS coronavirus SARS-CoV-2 pandemic may be particularly deleterious to patients with underlying cardiovascular disease (CVD). The mechanism for SARS-CoV-2 infection is the requisite… Expand
Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia.
- H. P. Jia, D. Look, +6 authors P. McCray
- Biology, Medicine
- American journal of physiology. Lung cellular and…
- 1 July 2009
Angiotensin-converting enzyme 2 (ACE2) is a terminal carboxypeptidase and the receptor for the SARS and NL63 coronaviruses (CoV). Loss of ACE2 function is implicated in severe acute respiratory… Expand
Angiotensin-(1–7) Prevents Activation of NADPH Oxidase and Renal Vascular Dysfunction in Diabetic Hypertensive Rats
- I. Benter, M. Yousif, G. Dhaunsi, Jaspal Kaur, M. Chappell, D. Diz
- American Journal of Nephrology
Background/Aim: We examined the influence of chronic treatment with angiotensin-(1–7) [Ang-(1–7)] on renox (renal NADPH oxidase, NOX-4) and the development of renal dysfunction in… Expand
Metabolism of angiotensin-(1-7) by angiotensin-converting enzyme.
Angiotensin converting enzyme (ACE) inhibitors augment circulating levels of the vasodilator peptide angiotensin-(1-7) [Ang-(1-7)] in man and animals. Increased concentrations of the peptide may… Expand
Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats.
- S. Lindsey, J. A. Cohen, K. B. Brosnihan, P. Gallagher, M. Chappell
- Biology, Medicine
- 1 August 2009
The mRen2.Lewis congenic strain is an estrogen-sensitive model of hypertension whereby estrogen depletion produces a significant and sustained increase in blood pressure. The recent identification of… Expand
Novel angiotensin peptides.
Virtually all existing evidence on the function of angiotensin II (Ang II) in the regulation of tissue homeostasis and blood pressure regulation bears on the more restricted question of what other… Expand
Vasodepressor actions of angiotensin-(1-7) unmasked during combined treatment with lisinopril and losartan.
Blockade of angiotensin II (Ang II) function during 8 days of oral therapy with lisinopril (20 mg/kg) and losartan (10 mg/kg) normalized the arterial pressure (112+/-3/70+/-3 mm Hg) and raised the… Expand
Estrogen regulation of angiotensin-converting enzyme mRNA.
Estrogen replacement therapy is cardioprotective in postmenopausal women; however, the precise molecular mechanisms for this modulation are not fully elucidated. We previously showed that chronic… Expand