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Disposition of chlordecone (Kepone®)in the rat is quantitated. Particular attention is devoted to the role of the intestinal… Expand Chlordecone (Kepone), a toxic organochlorine pesticide, undergoes bioreduction to chlordecone alcohol in human liver. This… Expand It has been established that the major metabolic pathway for chlordecone (CD) (Kepone) both in humans and in the Mongolian gerbil… Expand The biotransformation of chlordecone (CD) to chlordecone alcohol (CDOH) occurs in man and gerbils but not in rats, guinea pigs… Expand Partitioning of chlordecone, chlordecone alcohol, monohydrochlordecone, and dihydrochlordecone (2 to 100 microM) into isolated… Expand In seeking a practical animal model of chlordecone metabolism in humans, we found that among rats, hamsters, guinea pigs, or… Expand The hypothesis that liver is the site of the previously demonstrated chlordecone alcohol formation in man was tested. Human bile… Expand Workers exposed to chlordecone (Kepone), a toxic organochlorine pesticide, excreted larger amounts of chlordecone in bile than in… Expand Modern pest control methods by chemicals cause contamination of world waterways and thus endanger the life of aquatic fauna… Expand