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Treatment of chlordecone (Kepone) toxicity with cholestyramine. Results of a controlled clinical trial.
Industrial workers exposed to the organochlorine pesticide, chlordecone (Kepone), had signs of toxicity in several organs. The extent of toxicity was proportional to the levels of this chemical inExpand
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Stereoselective pharmacokinetics of 3,4-methylenedioxymethamphetamine in the rat.
Studies to characterize the pharmacokinetics of the enantiomers of MDMA were conducted in rats using the iliac arterial cannulation. Two routes of administration, intravenous and subcutaneous, wereExpand
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Chlordecone metabolism in the pig.
The biotransformation of chlordecone (CD) to chlordecone alcohol (CDOH) occurs in man and gerbils but not in rats, guinea pigs and hamsters [1, 2]. Because of the species differences in CDOHExpand
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Postmortem stability of benzodiazepines in blood and tissues.
The stability of benzodiazepines in blood and tissues was examined in this study. Specifically, diazepam, chlordiazepoxide, flurazepam, and their desalkyl metabolites were studied over severalExpand
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The effects of storage conditions on the stability of carbon monoxide in postmortem blood.
The stability of carbon monoxide (CO) in blood was studied under various conditions of storage using both spectrophotometric and gas chromatographic-flame ionization detector (GC-FID) methods ofExpand
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Excretion of chlordecone by the gastrointestinal tract: Evidence for a nonbiliary mechanism
Workers exposed to chlordecone (Kepone), a toxic organochlorine pesticide, excreted larger amounts of chlordecone in bile than in stool, suggesting that it may undergo enterohepatic recirculation. WeExpand
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Liver Structure and Function in Patients Poisoned with Chlordecone (Kepone)
Abstract A group of 32 men who worked in a factory that manufactured the organochlorine pesticide, chlordecone, had high levels of this chemical in samples of blood, adipose tissue and liver, andExpand
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Demonstration of major metabolic pathways for chlordecone (kepone) in humans.
The hypothesis that liver is the site of the previously demonstrated chlordecone alcohol formation in man was tested. Human bile obtained from chlordecone-poisoned factory workers containedExpand
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Preferential binding of chlordecone to the protein and high density lipoprotein fractions of plasma from humans and other species.
The preferential distribution of the relatively nonpolar pesticide chlordecone (CD) to liver rather than to fat tissues in humans suggests that it may be transported in plasma differently from otherExpand
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