chimmitecan
National Institutes of Health
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Aim:To investigate the pharmacokinetics and disposition of simmitecan (L-P) that was a water-soluble ester prodrug of chimmitecan…
Differential sensitivity of RIP3-proficient and deficient murine fibroblasts to camptothecin anticancer drugs
The invention provides a method for determining the content of simimtecan and chimmitecan in human or animal whole blood. The…
Camptothecins (CPT) activate S or G2-M arrest and the homologous recombination (HR) repair pathway in tumor cells. In this…
Purpose: This study aimed to evaluate antitumor activities and pharmacologic profiles of chimmitecan, a novel 9-small-alkyl…
Proc Amer Assoc Cancer Res, Volume 47, 2006
5529
Recently, lipophilic analogs of camptothecin are found to overcome the…