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changrolin

Known as: 4-(3',5'-bis(N-pyrrolidinyl)methyl)-(4'-hydroxyanilino)quinazoline, Phenol, 2,6-bis(1-pyrrolidinylmethyl)-4-(4-quinazolinylamino)- 
National Institutes of Health

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Broader (2)

Anti-Arrhythmia AgentsQuinazolines

Papers overview

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1989
1989
[Electrophysiological effects of changrolin on single ventricular myocytes isolated from adult guinea pig].
Calcium tolerant single ventricular cardiomyocytes were dispersed from adult guinea pig hearts by retrograde perfusion with… 
1989
1989
[Cytotoxic effects of changrolin, lidocaine and amiodarone on ultrastructure of cultured rat beating cardiac myocytes].
Ultrastructural and morphological alterations of cultured rat beating cardiac myocytes treated with changrolin (CRL), lidocaine… 
1987
1987
[Plasma drug concentration and cardiac function in arrhythmic patients during continuous drip of changrolin].
After changrolin was administered (2.5-3.5 mg/min) by iv drip for 4 or 8 h/d×2 d to 37 patients with rapid arrhythmia, the… 
1987
1987
[Electrophysiologic effects of changrolin on the cardiac conduction system in anesthetized rabbits].
The electrophysiologic effects of changrolin (CRL) and procainamide (PA) were evaluated in anesthetized rabbits by His-bundle… 
1985
1985
[Clinical pharmacokinetics of the anti-arrhythmic agent changrolin].
Changrolin is a new anti-arrhythmic agent. An intravenous drip of changrolin (55 μg/kg/min) for 60 rain was given to 11 patients… 
1984
1984
[Effects of changrolin on contractility and excitability of isolated cat papillary muscle].
Changrolin is a new anti-arrhythmic drug. Its effects on the contractility and excitability as well as its interaction with… 
1983
1983
[Effects of changrolin on electrophysiological properties of canine Purkinje fibers].
Histological identification of Purkinje fibers was carried out in 15 dogs. Action potential durations (APD) were found to be… 
1981
1981
Electrophysiological effects of changrolin, a new antiarrhythmic drug, on isolated cardiac preparations.
1980
1980
INFLUENCES OF COMBINED CHANGROLIN AND OTHER ANTIARRHYTHMIC DRUG TREATMENT ON ELECTRI-CALLY INDUCED VENTRICULAR FIBRILLATION THRESHOLD IN RABBIT
Experiments were performed in anesthetized rabbits.When Changrolin wasadministered intravenously alone in the doses ranging from… 
1979
1979
[Cardiovascular effect of a new antiarrhythmic drug--changrolin (author's transl)].