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changrolin

Known as: 4-(3',5'-bis(N-pyrrolidinyl)methyl)-(4'-hydroxyanilino)quinazoline, Phenol, 2,6-bis(1-pyrrolidinylmethyl)-4-(4-quinazolinylamino)- 
National Institutes of Health

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2 relations

Broader (2)

Anti-Arrhythmia AgentsQuinazolines

Papers overview

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1999
1999
Effects of changrolin on potassium currents in guinea pig and rabbit single heart cells.
AIM To elucidate whether or not changrolin (CRL) modifies the potassium currents (ITO, IK, and IKl) in myocardial cells… 
1995
1995
ELECTROPHYSIOLOGICAL EFFECTS OF CHANGROLIN, AN ANTIARRHYTHMIC AGENT DERIVED FROM DICHROA FEBRIFUGA, ON GUINEA‐PIG AND RABBIT HEART CELLS
1. The electrophysiological effects of changrolin (CRL), a Chinese antiarrhythmic drug derived from a traditional anti‐malarial… 
1989
1989
[Electrophysiological effects of changrolin on single ventricular myocytes isolated from adult guinea pig].
Calcium tolerant single ventricular cardiomyocytes were dispersed from adult guinea pig hearts by retrograde perfusion with… 
1987
1987
[Plasma drug concentration and cardiac function in arrhythmic patients during continuous drip of changrolin].
After changrolin was administered (2.5-3.5 mg/min) by iv drip for 4 or 8 h/d×2 d to 37 patients with rapid arrhythmia, the… 
1985
1985
[Clinical pharmacokinetics of the anti-arrhythmic agent changrolin].
Changrolin is a new anti-arrhythmic agent. An intravenous drip of changrolin (55 μg/kg/min) for 60 rain was given to 11 patients… 
1984
1984
Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 2. Amides.
Thirty amides patterned after the antiarrhythmic drug changrolin were synthesized and their antiarrhythmic and parasympatholytic… 
1984
1984
[Anti-arrhythmic effect of changrolin combined with nicotinamide in experimental arrhythmia].
Changrolin is a new anti-arrhythmic drug. The ED 50 of changrolin in combination with nicotinamide against chloroforminduced… 
1983
1983
[Effects of intravenous infusion of changrolin on cardiac function of patients with arrhythmia].
An iv infusion of changrolin, a new anti-arrhythmic drug, was given to 10 patients (3.3 mg/min for uo min). Among the 7 patients… 
1980
1980
INFLUENCES OF COMBINED CHANGROLIN AND OTHER ANTIARRHYTHMIC DRUG TREATMENT ON ELECTRI-CALLY INDUCED VENTRICULAR FIBRILLATION THRESHOLD IN RABBIT
Experiments were performed in anesthetized rabbits.When Changrolin wasadministered intravenously alone in the doses ranging from… 
1979
1979
Studies on a new antiarrhythmic drug changrolin-4-(3',5'-bis [(N-pyrrolidinyl) methyl]-4'-hydroxyanilino)-quinazoline.
Changrolin is 4-(3', 5'-bis[(N-pyrrolidinyl)methyl]-4'-hydroxyanilino)-quinazoline. It is a novel type of antidysrhythmic drug… 
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