cerivastatin

Known as: cerivastatin [Chemical/Ingredient] 
A synthetic lipid-lowering agent. Cerivastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which… (More)
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
A serious pharmacokinetic interaction between cerivastatin (CER) and gemfibrozil (GEM) has been reported. In the present study… (More)
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Highly Cited
2003
Highly Cited
2003
The mechanism involved in the clinically relevant drug-drug interaction (DDI) between cerivastatin (CER) and cyclosporin A (CsA… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Concomitant use of gemfibrozil with statins, particularly with cerivastatin, increases the risk of rhabdomyolysis, but… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Although statins preserve endothelial function by reducing serum cholesterol levels, it has been suggested they may… (More)
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Highly Cited
2002
Highly Cited
2002
We previously have found that advanced glycation end products (AGE), senescent macroproteins formed at an accelerated rate in… (More)
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Highly Cited
2001
Highly Cited
2001
Cerivastatin was recently withdrawn from the market because of 52 deaths attributed to drug-related rhabdomyolysis that lead to… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Unstable atherosclerotic plaques that cause acute coronary events usually contain abundant macrophages expressing… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Long-term therapy with hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) has been shown to reduce levels… (More)
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Highly Cited
2001
Highly Cited
2001
Cerivastatin is used in the treatment of hypercholesterolemia to inhibit 3-hydroxy 3-methylglutaryl coenzyme A reductase and thus… (More)
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Highly Cited
2000
Highly Cited
2000
Development of severe sepsis is thought to result from the overproduction of cytokines, such as tumor necrosis factor-alpha (TNF… (More)
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