cellular response to DNA damage stimulus

Known as: cellular DNA damage response, DNA damage response, response to genotoxic stress 
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a… (More)
National Institutes of Health

Papers overview

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Review
2016
Review
2016
DNA damage plays a causal role in numerous human pathologies including cancer, premature aging, and chronic inflammatory… (More)
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Highly Cited
2011
Highly Cited
2011
Cellular senescence suppresses cancer by forcing potentially oncogenic cells into a permanent cell cycle arrest. Senescent cells… (More)
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Highly Cited
2011
Highly Cited
2011
A better understanding of the mechanisms through which anticancer drugs exert their effects is essential to improve combination… (More)
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Highly Cited
2010
Highly Cited
2010
Double-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for… (More)
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Highly Cited
2007
Highly Cited
2007
Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and… (More)
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Review
2007
Review
2007
DNA damage response (DDR), the guardian of genomic integrity, emerges as an oncogene-inducible biological barrier against… (More)
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Review
2007
Review
2007
The DNA damage response (DDR), through the action of sensors, transducers, and effectors, orchestrates the appropriate repair of… (More)
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Highly Cited
2004
Highly Cited
2004
The telomeric protein TRF2 is required to prevent mammalian telomeres from activating DNA damage checkpoints. Here we show that… (More)
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Highly Cited
2002
Highly Cited
2002
The Period2 gene plays a key role in controlling circadian rhythm in mice. We report here that mice deficient in the mPer2 gene… (More)
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Highly Cited
1998
Highly Cited
1998
Nijmegen breakage syndrome (NBS) is an autosomal recessive disorder characterized by increased cancer incidence, cell cycle… (More)
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