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cefazedone

Known as: (6R,7R)-7-(2-(3,5-Dichloro-4-oxo-1(4H)-pyridyl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-carboxylic Acid, (6R-trans)7-(((3,5-dichloro-4-oxo- 1(4H)-pyridinyl)acetyl)amino)-3-(((5-methyl- 1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oxy-2-ene-2-carbox ylic acid, 7-(2-(3,5-dichloro-4-oxo-1- pyridyl)acetamido)-3-(5-methyl-1,3,4-thiadiazol- 2-ylthiomethyl)-3-cephem-4-carboxylic acid 
A semisynthetic first-generation cephalosporin with antibacterial activity. Cefazedone binds to and inactivates penicillin-binding proteins (PBPs… Expand
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Anti-Bacterial AgentsCefazolin

Narrower (2)

Refosporencefazedone sodium
analogs & derivatives

Papers overview

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2013
2013
Influence of the Type of Viscosity-Modifying Admixtures and Metakaolin on the Rheology of Grouts
The Viscosity-modifying admixtures (VMAs) contribute to the control of the rheology of grouts and are used to enhance plastic… Expand
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2010
2010
Investigation of the toxic functional group of cephalosporins by zebrafish embryo toxicity test.
2-mercapto-5-methyl-1,3,4-thiadiazole (MMTD) is the 3'-side chain of cephalosporin including cefazolin sodium (CFZL) and… Expand
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2009
2009
Poly(N-isopropylacrylamide), poly(methacrylic acid) and their copolymers for oral colon-specific drug delivery
A series of cross-linked gels of Poly(N-isopropylacrylamide) [P(NIPAAm)] and Poly(methacr-ylic acid)[P(MAA)] homopolymers and P… Expand
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1988
1988
Cephalosporin-induced immune cytopenia in the dog: demonstration of erythrocyte-, neutrophil-, and platelet-associated IgG following treatment with cefazedone.
Cephalosporin treatment in man has been associated with a low incidence of hemolytic anemia, thrombocytopenia, and neutropenia… Expand
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1987
1987
The hematologic effects of cefonicid and cefazedone in the dog: a potential model of cephalosporin hematotoxicity in man.
Cephalosporin antibiotics cause a variety of hematologic disturbances in man, the pathogeneses and hematopathology of which… Expand
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1979
1979
Investigations on the potential nephrotoxicity of cefazedone and gentamicin and of their combination, in comparison with the combination of cefazolin and cephalothin with gentamicin.
The nephrotoxicity of (6R,7R)-7-(2-[3,5-Dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl… Expand
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1979
1979
Clinical evaluation of cefazedone.
The results of clinical trials with (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2… Expand
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1979
1979
Microbiological activity of cefazedone as compared to cefazolin and cephalothin.
In a comparison of the antibacterial activity of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([5-methyl-1,3,4… Expand
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1979
1979
Antibiotic activity of cefazedone in experimental pyelonephritis.
The new cephalosporin derivative (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl… Expand
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1979
1979
Bactericidal activity of cefazedone.
Distinct bactericidal activity of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl… Expand
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