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cefazedone

Known as: (6R,7R)-7-(2-(3,5-Dichloro-4-oxo-1(4H)-pyridyl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-carboxylic Acid, (6R-trans)7-(((3,5-dichloro-4-oxo- 1(4H)-pyridinyl)acetyl)amino)-3-(((5-methyl- 1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oxy-2-ene-2-carbox ylic acid, 7-(2-(3,5-dichloro-4-oxo-1- pyridyl)acetamido)-3-(5-methyl-1,3,4-thiadiazol- 2-ylthiomethyl)-3-cephem-4-carboxylic acid 
A semisynthetic first-generation cephalosporin with antibacterial activity. Cefazedone binds to and inactivates penicillin-binding proteins (PBPs… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Anti-Bacterial AgentsCefazolin

Narrower (2)

Refosporencefazedone sodium
analogs & derivatives

Papers overview

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2011
2011
In vitro activities of cefazedone against clinical isolates
Objective To evaluate the in vitro activity of cefazedone.MethodsThe minimum inhibitory concentrations(MICs) of cefazedone… 
1980
1980
[Pharmacokinetics and tolerance of Cefazedone compared with Cefazoline (author's transl)].
In a randomized cross over study Cefazoline and Cefazedone were administered i.v. as injection of 2 minutes duration and as… 
1979
1979
Blood levels and tissue concentrations of cefazedone in animals.
In mice, dogs, and rabbits blood and serum levels were evaluated after parenteral application of (6R,7R)-7-(2-[3,5-dichloro-4-oxo… 
1979
1979
Investigations on the action of cefazedone and gentamicin, alone and combined, on renal enzyme excretion in rats.
Administration of (6R, 7 R)-7-(2-[3,5-dichloro-4-oxo-1(4 H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl… 
1979
1979
Investigations on the potential nephrotoxicity of cefazedone and gentamicin and of their combination, in comparison with the combination of cefazolin and cephalothin with gentamicin.
The nephrotoxicity of (6R,7R)-7-(2-[3,5-Dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl… 
1979
1979
Experimental investigations of the renal tolerance of cefazedone.
Renal tolerance tests in Wistar rats (n = 40) over 12 days showed that the tubulotoxic threshold dose of the cephalosporin… 
1979
1979
Clinical pharmacology phase I of cefazedone, a new cephalosporin, in healthy volunteers. II. Pharmacokinetics in comparison with cefazolin.
In two consecutive cross-over studies, each involving 10 healthy volunteers, the pharmacokinetics of (6R,7R)-7-(2-[3,5-dichloro-4… 
1979
1979
Short- and long-term toxicological studies on cefazedone.
1979
1979
Investigations on group allergy reactions to cefazedone in patients with penicillin allergy of the anaphylactic type (type I) and of the delayed type (type IV).
Allergological investigations (scratch test, intracutaneous test, RAST test, patch test) on 19 patients displaying allergies of… 
1979
1979
Cefazedone: microbiological evaluation in comparison with cephalothin and cefazolin.