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cefazedone
Known as:
(6R,7R)-7-(2-(3,5-Dichloro-4-oxo-1(4H)-pyridyl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-carboxylic Acid
, (6R-trans)7-(((3,5-dichloro-4-oxo- 1(4H)-pyridinyl)acetyl)amino)-3-(((5-methyl- 1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oxy-2-ene-2-carbox ylic acid
, 7-(2-(3,5-dichloro-4-oxo-1- pyridyl)acetamido)-3-(5-methyl-1,3,4-thiadiazol- 2-ylthiomethyl)-3-cephem-4-carboxylic acid
A semisynthetic first-generation cephalosporin with antibacterial activity. Cefazedone binds to and inactivates penicillin-binding proteins (PBPs…
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National Institutes of Health
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Related topics
Related topics
5 relations
Broader (2)
Anti-Bacterial Agents
Cefazolin
Narrower (2)
Refosporen
cefazedone sodium
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Investigation of the Toxic Functional Group of Cephalosporins by Zebrafish Embryo Toxicity Test
Jingpu Zhang
,
J. Meng
,
Ya-ping Li
,
Changqin Hu
Archiv der Pharmazie
2010
Corpus ID: 24920066
2‐mercapto‐5‐methyl‐1,3,4‐thiadiazole (MMTD) is the 3'‐side chain of cephalosporin including cefazolin sodium (CFZL) and…
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2009
2009
Poly(N-isopropylacrylamide), poly(methacrylic acid) and their copolymers for oral colon-specific drug delivery
Yuxiang Gao
,
Xingmin Ji
,
Yihua Yin
,
Hui Dong
,
Hua Zheng
2009
Corpus ID: 95887491
A series of cross-linked gels of Poly(N-isopropylacrylamide) [P(NIPAAm)] and Poly(methacr-ylic acid)[P(MAA)] homopolymers and P…
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1988
1988
Cephalosporin‐induced immune cytopenia in the dog: Demonstration of erythrocyte‐, neutrophil‐, and platelet‐associated igg following treatment with cefazedone
J. Bloom
,
P. Thiem
,
T. Sellers
,
H. Lewis
,
A. Deldar
American journal of hematology/oncology
1988
Corpus ID: 23039950
Cephalosporin treatment in man has been associated with a low incidence of hemolytic anemia, thrombocytopenia, and neutropenia…
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1988
1988
Cephalosporin-induced alterations in erythroid (CFU-E) and granulocyte-macrophage (CFU-GM) colony-forming capacity in canine bone marrow
A. Deldar
,
H. Lewis
,
J. Bloom
,
L. Weiss
1988
Corpus ID: 208283757
1988
1988
Cephalosporin-induced Changes in the Ultrastructure of Canine Bone Marrow
A. Deldar
,
H. Lewis
,
J. Bloom
,
L. Weiss
Veterinary Pathology-Supplement
1988
Corpus ID: 36105777
Fourteen healthy dogs were given 540 to 840 mg/kg of cefazedone (Refosporen®) intravenously for up to 4 months or until…
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1984
1984
Failure of cephalosporins to cure experimental listeriosis.
B. Kawaler
,
H. Hof
Journal of Infection
1984
Corpus ID: 3791923
1982
1982
A comparison of the antibacterial activities of N-formimidoyl thienamycin (MK0787) with those of other recently developed beta-lactam derivatives
W. Cullmann
,
W. Opferkuch
,
M. Stieglitz
,
U. Werkmeister
Antimicrobial Agents and Chemotherapy
1982
Corpus ID: 27288108
The antibacterial activity of N-formimidoyl thienamycin (MK0787) was evaluated in 335 clinical isolates of ampicillin-resistant…
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Review
1981
Review
1981
Penicillins, cephalosporins and tetracyclines
B. Klingeren
1981
Corpus ID: 58750902
1979
1979
Investigations on the potential nephrotoxicity of cefazedone and gentamicin and of their combination, in comparison with the combination of cefazolin and cephalothin with gentamicin.
Mondorf Aw
1979
Corpus ID: 102379658
The nephrotoxicity of (6R,7R)-7-(2-[3,5-Dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl…
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1979
1979
Microbiological activity of cefazedone as compared to cefazolin and cephalothin.
H. Knothe
Arzneimittel-Forschung
1979
Corpus ID: 41181233
In a comparison of the antibacterial activity of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([5-methyl-1,3,4…
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