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cefazedone

Known as: (6R,7R)-7-(2-(3,5-Dichloro-4-oxo-1(4H)-pyridyl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-carboxylic Acid, (6R-trans)7-(((3,5-dichloro-4-oxo- 1(4H)-pyridinyl)acetyl)amino)-3-(((5-methyl- 1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oxy-2-ene-2-carbox ylic acid, 7-(2-(3,5-dichloro-4-oxo-1- pyridyl)acetamido)-3-(5-methyl-1,3,4-thiadiazol- 2-ylthiomethyl)-3-cephem-4-carboxylic acid 
A semisynthetic first-generation cephalosporin with antibacterial activity. Cefazedone binds to and inactivates penicillin-binding proteins (PBPs… Expand
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Anti-Bacterial AgentsCefazolin

Narrower (2)

Refosporencefazedone sodium
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Investigation of the Toxic Functional Group of Cephalosporins by Zebrafish Embryo Toxicity Test
2‐mercapto‐5‐methyl‐1,3,4‐thiadiazole (MMTD) is the 3'‐side chain of cephalosporin including cefazolin sodium (CFZL) and… Expand
2009
2009
Poly(N-isopropylacrylamide), poly(methacrylic acid) and their copolymers for oral colon-specific drug delivery
A series of cross-linked gels of Poly(N-isopropylacrylamide) [P(NIPAAm)] and Poly(methacr-ylic acid)[P(MAA)] homopolymers and P… Expand
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1988
1988
Cephalosporin‐induced immune cytopenia in the dog: Demonstration of erythrocyte‐, neutrophil‐, and platelet‐associated igg following treatment with cefazedone
Cephalosporin treatment in man has been associated with a low incidence of hemolytic anemia, thrombocytopenia, and neutropenia… Expand
1988
1988
Cephalosporin-induced Changes in the Ultrastructure of Canine Bone Marrow
Fourteen healthy dogs were given 540 to 840 mg/kg of cefazedone (Refosporen®) intravenously for up to 4 months or until… Expand
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1987
1987
The hematologic effects of cefonicid and cefazedone in the dog: a potential model of cephalosporin hematotoxicity in man.
Cephalosporin antibiotics cause a variety of hematologic disturbances in man, the pathogeneses and hematopathology of which… Expand
1987
1987
The hematopathology of cefonicid- and cefazedone-induced blood dyscrasias in the dog.
Cephalosporin treatment in man has been associated with blood dyscrasias that include a time- and dose-related anemia… Expand
1982
1982
A comparison of the antibacterial activities of N-formimidoyl thienamycin (MK0787) with those of other recently developed beta-lactam derivatives.
The antibacterial activity of N-formimidoyl thienamycin (MK0787) was evaluated in 335 clinical isolates of ampicillin-resistant… Expand
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1979
1979
Blood levels and tissue concentrations of cefazedone in animals.
In mice, dogs, and rabbits blood and serum levels were evaluated after parenteral application of (6R,7R)-7-(2-[3,5-dichloro-4-oxo… Expand
1979
1979
Investigations on the potential nephrotoxicity of cefazedone and gentamicin and of their combination, in comparison with the combination of cefazolin and cephalothin with gentamicin.
The nephrotoxicity of (6R,7R)-7-(2-[3,5-Dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl… Expand
1979
1979
Investigations on the action of cefazedone and gentamicin, alone and combined, on renal enzyme excretion in rats.
  • W. Raab
  • Arzneimittel-Forschung
  • 1979
    • Corpus ID: 45749562
Administration of (6R, 7 R)-7-(2-[3,5-dichloro-4-oxo-1(4 H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl… Expand
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