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cefazedone

Known as: (6R,7R)-7-(2-(3,5-Dichloro-4-oxo-1(4H)-pyridyl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-carboxylic Acid, (6R-trans)7-(((3,5-dichloro-4-oxo- 1(4H)-pyridinyl)acetyl)amino)-3-(((5-methyl- 1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oxy-2-ene-2-carbox ylic acid, 7-(2-(3,5-dichloro-4-oxo-1- pyridyl)acetamido)-3-(5-methyl-1,3,4-thiadiazol- 2-ylthiomethyl)-3-cephem-4-carboxylic acid 
A semisynthetic first-generation cephalosporin with antibacterial activity. Cefazedone binds to and inactivates penicillin-binding proteins (PBPs… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Anti-Bacterial AgentsCefazolin

Narrower (2)

Refosporencefazedone sodium
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Poly(N-isopropylacrylamide), poly(methacrylic acid) and their copolymers for oral colon-specific drug delivery
A series of cross-linked gels of Poly(N-isopropylacrylamide) [P(NIPAAm)] and Poly(methacr-ylic acid)[P(MAA)] homopolymers and P… 
1988
1988
Cephalosporin-induced alterations in erythroid (CFU-E) and granulocyte-macrophage (CFU-GM) colony-forming capacity in canine bone marrow
1988
1988
Cephalosporin-induced Changes in the Ultrastructure of Canine Bone Marrow
Fourteen healthy dogs were given 540 to 840 mg/kg of cefazedone (Refosporen®) intravenously for up to 4 months or until… 
1979
1979
Investigations on the action of cefazedone and gentamicin, alone and combined, on renal enzyme excretion in rats.
Administration of (6R, 7 R)-7-(2-[3,5-dichloro-4-oxo-1(4 H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl… 
1979
1979
Microbiological activity of cefazedone as compared to cefazolin and cephalothin.
In a comparison of the antibacterial activity of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([5-methyl-1,3,4… 
1979
1979
Blood levels and tissue concentrations of cefazedone in animals.
In mice, dogs, and rabbits blood and serum levels were evaluated after parenteral application of (6R,7R)-7-(2-[3,5-dichloro-4-oxo… 
1979
1979
Antibiotic activity of cefazedone in experimental pyelonephritis.
The new cephalosporin derivative (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl… 
1979
1979
Investigations on the potential nephrotoxicity of cefazedone and gentamicin and of their combination, in comparison with the combination of cefazolin and cephalothin with gentamicin.
The nephrotoxicity of (6R,7R)-7-(2-[3,5-Dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl… 
1979
1979
Bactericidal activity of cefazedone.
Distinct bactericidal activity of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl… 
1946
1946
Antifibrillating Action of N-Methyl-Dibenzyl-Amine and Some of Its Derivatives
Summary The antifibrillating activity of a series of tertiary bases with a carbon skeleton related to the possible chemical… 
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