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cefazedone

Known as: (6R,7R)-7-(2-(3,5-Dichloro-4-oxo-1(4H)-pyridyl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-carboxylic Acid, (6R-trans)7-(((3,5-dichloro-4-oxo- 1(4H)-pyridinyl)acetyl)amino)-3-(((5-methyl- 1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oxy-2-ene-2-carbox ylic acid, 7-(2-(3,5-dichloro-4-oxo-1- pyridyl)acetamido)-3-(5-methyl-1,3,4-thiadiazol- 2-ylthiomethyl)-3-cephem-4-carboxylic acid 
A semisynthetic first-generation cephalosporin with antibacterial activity. Cefazedone binds to and inactivates penicillin-binding proteins (PBPs… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Anti-Bacterial AgentsCefazolin

Narrower (2)

Refosporencefazedone sodium
analogs & derivatives

Papers overview

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2010
2010
Investigation of the Toxic Functional Group of Cephalosporins by Zebrafish Embryo Toxicity Test
2‐mercapto‐5‐methyl‐1,3,4‐thiadiazole (MMTD) is the 3'‐side chain of cephalosporin including cefazolin sodium (CFZL) and… 
2009
2009
Poly(N-isopropylacrylamide), poly(methacrylic acid) and their copolymers for oral colon-specific drug delivery
A series of cross-linked gels of Poly(N-isopropylacrylamide) [P(NIPAAm)] and Poly(methacr-ylic acid)[P(MAA)] homopolymers and P… 
1988
1988
Cephalosporin‐induced immune cytopenia in the dog: Demonstration of erythrocyte‐, neutrophil‐, and platelet‐associated igg following treatment with cefazedone
Cephalosporin treatment in man has been associated with a low incidence of hemolytic anemia, thrombocytopenia, and neutropenia… 
1988
1988
Cephalosporin-induced alterations in erythroid (CFU-E) and granulocyte-macrophage (CFU-GM) colony-forming capacity in canine bone marrow
1988
1988
Cephalosporin-induced Changes in the Ultrastructure of Canine Bone Marrow
Fourteen healthy dogs were given 540 to 840 mg/kg of cefazedone (Refosporen®) intravenously for up to 4 months or until… 
1984
1984
Failure of cephalosporins to cure experimental listeriosis.
1982
1982
A comparison of the antibacterial activities of N-formimidoyl thienamycin (MK0787) with those of other recently developed beta-lactam derivatives
The antibacterial activity of N-formimidoyl thienamycin (MK0787) was evaluated in 335 clinical isolates of ampicillin-resistant… 
Review
1981
Review
1981
Penicillins, cephalosporins and tetracyclines
1979
1979
Investigations on the potential nephrotoxicity of cefazedone and gentamicin and of their combination, in comparison with the combination of cefazolin and cephalothin with gentamicin.
The nephrotoxicity of (6R,7R)-7-(2-[3,5-Dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl… 
1979
1979
Microbiological activity of cefazedone as compared to cefazolin and cephalothin.
  • H. Knothe
  • Arzneimittel-Forschung
  • 1979
  • Corpus ID: 41181233
In a comparison of the antibacterial activity of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([5-methyl-1,3,4… 
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