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cefazedone

Known as: (6R,7R)-7-(2-(3,5-Dichloro-4-oxo-1(4H)-pyridyl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-carboxylic Acid, (6R-trans)7-(((3,5-dichloro-4-oxo- 1(4H)-pyridinyl)acetyl)amino)-3-(((5-methyl- 1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oxy-2-ene-2-carbox ylic acid, 7-(2-(3,5-dichloro-4-oxo-1- pyridyl)acetamido)-3-(5-methyl-1,3,4-thiadiazol- 2-ylthiomethyl)-3-cephem-4-carboxylic acid 
A semisynthetic first-generation cephalosporin with antibacterial activity. Cefazedone binds to and inactivates penicillin-binding proteins (PBPs… Expand
National Institutes of Health

Papers overview

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2010
2010
2‐mercapto‐5‐methyl‐1,3,4‐thiadiazole (MMTD) is the 3'‐side chain of cephalosporin including cefazolin sodium (CFZL) and… Expand
2009
2009
A series of cross-linked gels of Poly(N-isopropylacrylamide) [P(NIPAAm)] and Poly(methacr-ylic acid)[P(MAA)] homopolymers and P… Expand
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1988
1988
Cephalosporin treatment in man has been associated with a low incidence of hemolytic anemia, thrombocytopenia, and neutropenia… Expand
1988
1988
Fourteen healthy dogs were given 540 to 840 mg/kg of cefazedone (Refosporen®) intravenously for up to 4 months or until… Expand
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1987
1987
Cephalosporin antibiotics cause a variety of hematologic disturbances in man, the pathogeneses and hematopathology of which… Expand
1987
1987
Cephalosporin treatment in man has been associated with blood dyscrasias that include a time- and dose-related anemia… Expand
1982
1982
The antibacterial activity of N-formimidoyl thienamycin (MK0787) was evaluated in 335 clinical isolates of ampicillin-resistant… Expand
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1979
1979
In mice, dogs, and rabbits blood and serum levels were evaluated after parenteral application of (6R,7R)-7-(2-[3,5-dichloro-4-oxo… Expand
1979
1979
The nephrotoxicity of (6R,7R)-7-(2-[3,5-Dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl… Expand
1979
1979
  • W. Raab
  • Arzneimittel-Forschung
  • 1979
  • Corpus ID: 45749562
Administration of (6R, 7 R)-7-(2-[3,5-dichloro-4-oxo-1(4 H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl… Expand