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cathepsin B activity

OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2018
0102019672018

Papers overview

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Highly Cited
2008
Highly Cited
2008
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Inhalation of silica crystals causes inflammation in the alveolar space. Prolonged exposure to silica can lead to the development… (More)
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Highly Cited
2002
Highly Cited
2002
In vivo imaging of proteolytic activity in atherosclerosis.
BACKGROUND Atherosclerotic plaque rupture, the most important cause of acute cardiovascular incidents, has been strongly… (More)
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1999
1999
Exocytosis of active cathepsin B enzyme activity at pH 7.0, inhibition and molecular mass.
Lysosomal cathepsin B has been implicated in parasitic, inflammatory and neoplastic diseases. Most of these pathologies suggest a… (More)
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1997
1997
Role of the occluding loop in cathepsin B activity.
Within the lysosomal cysteine protease family, cathepsin B is unique due to its ability to act both as an endopeptidase and a… (More)
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Highly Cited
1997
Highly Cited
1997
Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes.
BACKGROUND & AIMS Bile salt-induced apoptosis is mediated by a trypsin-like nuclear protease. The aims of this study were to… (More)
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1995
1995
Increased cathepsin B activity in multiple sclerosis brain.
Cathepsin B (CB) activity was measured in aqueous extracts of frozen autopsy specimens of centrum semiovale from three MS… (More)
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Highly Cited
1994
Highly Cited
1994
Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples.
Gelatinase A (MMP-2) and cathepsin B are proteinases which have been proposed to participate in human tumor invasion and… (More)
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Highly Cited
1992
Highly Cited
1992
Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues.
Our laboratory has previously demonstrated that increased malignancy of several histological types of human and animal tumours is… (More)
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1982
1982
Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.
In solid s.c. tumors of a variant of the murine B16 melanoma with high metastatic potential (B16F10), there was a 2- to 7-fold… (More)
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Highly Cited
1981
Highly Cited
1981
Lysosomal cathepsin B: correlation with metastatic potential.
Although lysosomal enzymes are implicated in the processes of tumor invasion and metastasis, their cellular origin within the… (More)
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