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Tenascin-C contains distinct adhesive, anti-adhesive, and neurite outgrowth promoting sites for neurons
Observations suggest that TN-C harbors distinct cell- binding, repulsive, and neurite outgrowth promoting sites for neurons, and the properties of isoform-specificTN-C domains suggest functional significance of the alternative splicing of TN- C glycoproteins.
J1-160 and J1-180 are oligodendrocyte-secreted nonpermissive substrates for cell adhesion
Members of the two groups of glia-derived J1 extracellular matrix glycoproteins show distinct cross-reactivities and the repulsive effect toward neurons can be neutralized by one of the monoclonal antibodies, but not by the other.
Ionomycin-activated Calpain Triggers Apoptosis
- S. Gil-Parrado, A. Fernández-Montalván, W. Machleidt
- Biology, ChemistryThe Journal of Biological Chemistry
- 26 July 2002
It is concluded that ionomycin-induced calpain activation promotes decrease of Bcl-2 proteins thereby triggering the intrinsic apoptotic pathway.
Loss of Drop1 expression already at early tumor stages in a wide range of human carcinomas
CDNA arrays of matched pairs of tumor and normal tissue and in situ hybridizations confirmed the drastic loss of Drop1 mRNA as a common feature in uterus, cervix, kidney, lung, thyroid and pancreas carcinomas and two‐hybrid studies suggest a role of this deficiency in the malignant progression of epithelial tumors.
Imbalance between cathepsin-B and cysteine proteinase-inhibitors is of prognostic-significance in human lung-cancer.
- H. Knoch, B. Werle, W. Ebert, E. Spiess
- Medicine, BiologyInternational journal of oncology
- 1 July 1994
It is concluded, that the imbalance between the activities of CB and CPIs is of prognostic significance in lung tumor patients.
Subcellular Localization and in VivoSubunit Interactions of Ubiquitous μ-Calpain*
It is proposed that intracellular localization and in particular membrane targeting of activated calpain, but not dissociation of its intact subunits, contribute to regulate its proteolytic activity in vivo.
Cathepsin B, plasminogenactivator-inhibitor (PAI-1) and plasminogenactivator-receptor (uPAR) are prognostic factors for patients with non-small cell lung cancer.
Among 10 biological parameters evaluated within the same cohort of patients, only PAI-1, upar (ADI), uPAR (HD13), u PAR (IIIF10), Cath B(AT) and cath B(C) are prognostic factors for overall survival of NSCLC patients.
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
- B. Werle, W. Ebert, W. Klein, E. Spiess
- Biology, MedicineBiological chemistry Hoppe-Seyler
- 1 March 1995
In a series of pairs of lung tumor tissue and non-tumor lung parenchyma from 50 patients, it could be demonstrated that significant amount of cathepsin L is complexed with the cysteine proteinase inhibitor kininogen, which explains the rather low cathePSin L activity values in the tissue extracts.
Cystatins in non-small cell lung cancer: tissue levels, localization and relation to prognosis.
Only stefins A and B, i.e. type I cystatins, are up-regulated in lung tumours and thus able to counteract harmful tumour-associated proteolytic activity, and may add independent prognostic information for better assessment of low- and high-risk patients with NSCLC.
Purified glucocorticoid receptor-hormone complex from rat liver cytosol binds specifically to cloned mouse mammary tumor virus long terminal repeats in vitro.
- M. Govindan, E. Spiess, J. Majors
- BiologyProceedings of the National Academy of Sciences…
- 1 September 1982
The hypothesis that HRC regulates hormone-induced transcription by binding to specific DNA sequences near the MMTV transcription start site is supported.