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carzelesin

Known as: 2-Benzofurancarboxamide, N-(2-((1-(chloromethyl)-1,6-dihydro-8-methyl-5-(((phenylamino)carbonyl)oxy)benzo(1,2-b:4,3-b')dipyrrol-3(2H)-yl)carbonyl)-1H-indol-5-yl)-6-(diethylamino)-, (S)- 
A cyclopropylpyrroloindole prodrug analogue and DNA minor groove binding agent, with antineoplastic activity. After hydrolysis, the cyclopropyl group… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

BenzofuransIndoles

Narrower (1)

U 80244

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
Comparative activity of the cyclopropylpyrroloindole compounds adozelesin, bizelesin and carzelesin in a human tumor colony-forming assay.
Adozelesin, bizelesin and carzelesin are synthetic cyclopropylpyrroloindole (CPI) analogs, a class of potent antineoplastic… 
1998
1998
Sequence selectivity of DNA alkylation by adozelesin and carzelesin
Adozelesin and carzelesin are synthetic analogues of the extremely potent antitumor antibiotic CC-1065, which alkylates N3 of… 
1998
1998
Comparative pharmacology of the novel cyclopropylpyrroloindole-prodrug carzelesin in mice, rats, and humans.
Carzelesin is a novel cyclopropylpyrroloindole prodrug analogue that has recently been tested in Phase I clinical trials. To… 
Review
1997
Review
1997
DNA minor groove binding ligands: a new class of anticancer agents.
This paper gives an overview of the available pharmacological and clinical data of a new class of anticancer drugs which act by… 
1997
1997
Hematopoietic toxicity and cell cycle perturbations induced by new DNA minor groove–alkylating agents
Some new alkylating agents which bind to the minor groove of DNA and have sequence‐specific patterns of alkylation have shown… 
1996
1996
Systematic study on the chemical stability of the prodrug antitumor agent carzelesin (U-80,244)
The chemical stability of the novel anticancer agent carzelesin in aqueous buffer/acetonitrile (1:1, v/v) mixtures has been… 
1996
1996
CARZELESIN : ANTINEOPLASTIC, ALKYLATING AGENT
1995
1995
The influence of formulation excipients on the stability of the novel antitumor agent carzelesin (U-80,244).
The stability of carzelesin in a polyethylene glycol 400 (PEG 400)/absolute ethanol/polysorbate 80 (Tween 80) (6:3:1, v/v/v… 
1994
1994
Fully automated high-performance liquid chromatographic method for the determination of carzelesin (U-80,244) and metabolites (U-76,073 and U-76,074) in human plasma.
Review
1992
Review
1992
Laboratory and phase I studies of new cancer drugs
New drug discovery continues to follow the time-honored paths of screening and novel target identification combined with analogue… 
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