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carmegliptin

Known as: (4S)-1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1- a]isoquinolin-3-yl]-4-(fluoromethyl)pyrrolidin-2-one 
A potent, long-acting, selective, orally bioavailable, pyrrolidinone-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity… 
National Institutes of Health

Related topics

Related topics

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Broader (1)

Quinolizines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Use of Cyclopropane as C1 Synthetic Unit by Directed Retro-Cyclopropanation with Ethylene Release.
Cyclopropanation of alkenes is a well-established textbook reaction for the synthesis of cyclopropanes, where a "high-energy… 
2015
2015
Retrospective and Prospective Human Intravenous and Oral Pharmacokinetic Projection of Dipeptidyl peptidase-IV Inhibitors Using Simple Allometric Principles - Case Studies of ABT-279, ABT-341…
PURPOSE The purpose of this exercise was to explore the utility of allometric scaling approach for the prediction of intravenous… 
2012
2012
Ligand-based pharmacophore detection, screening of potential gliptins and docking studies to get effective antidiabetic agents.
Three-dimensional pharmacophore hypothesis was established based on a set of known DPP-IV inhibitor using PharmaGist software… 
2010
2010
Pharmacokinetics and metabolism of the dipeptidyl peptidase IV inhibitor carmegliptin in rats, dogs, and monkeys
The pharmacokinetics and excretion of carmegliptin, a novel dipeptidyl peptidase IV inhibitor, were examined in rats, dogs, and… 
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