capmatinib

Known as: 2-Fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide 
An orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2015-2017
02420152017

Papers overview

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Review
2018
Review
2018
Aberrant c-Met activity has been implicated in the development of hepatocellular carcinoma (HCC), suggesting that c-Met… (More)
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2017
2017
Sorafenib displays a limited efficacy for advanced hepatocellular carcinoma (HCC). Some patients with HCC initially respond to… (More)
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2017
2017
Although many epidermal growth factor receptor (EGFR)-mutated lung cancer patients initially benefit from the EGFR-inhibitor… (More)
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2017
2017
Background Third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) such as osimertinib are the… (More)
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Review
2017
Review
2017
A number of small molecule tyrosine kinase inhibitors (TKIs) have now been approved for the treatment of non-small cell lung… (More)
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Review
2017
Review
2017
Non-small cell lung cancer (NSCLC) inevitably develops resistance to epidermal growth factor receptor (EGFR) tyrosine kinase… (More)
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2016
2016
The receptor tyrosine kinase mesenchymal-epithelial transition factor (c-Met) sits at the interface between controlled cellular… (More)
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2016
2016
PURPOSE To test second-line personalized medicine combination therapies, based on genomic and proteomic data, in patient-derived… (More)
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2016
2016
Patient-derived xenografts (PDXs) that are generated by transplanting fresh human tumor tissue into immunodeficient mice (avatars… (More)
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2015
2015
802 | CANCER DISCOVERY AUGUST 2015 www.aacrjournals.org 1 Mary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center… (More)
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