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Most Ca2+-permeable ion channels are inhibited by increases in the intracellular Ca2+ concentration ([Ca2+]i), thus preventing… Expand Autism is a psychiatric disorder with estimated heritability of 90%. One-third of autistic individuals experience seizures. A… Expand Calcium-calmodulin-dependent protein kinase II (CaMKII) is thought to increase synaptic strength by phosphorylating postsynaptic… Expand The mechanism of superoxide generation by endothelial nitric oxide synthase (eNOS) was investigated by the electron spin… Expand Neuromodulin (also designated P-57, GAP-43, B-50) is a major presynaptic substrate for protein kinase C. Phosphorylation of… Expand We have evaluated the possibility that a major, abundant cellular substrate for protein kinase C might be a calmodulin-binding… Expand Regulatory domains of the multifunctional Ca2+/calmodulin-dependent protein kinase II were investigated utilizing synthetic… Expand P-57 is a neural-specific calmodulin binding protein with novel calmodulin binding properties. P-57 exhibits higher affinity for… Expand A protein kinase phosphorylation site in chicken gizzard myosin light chain kinase (MLCK) has been identified, and a synthetic… Expand The free energy of coupling for binding of Ca2+ and the calmodulin-sensitive phosphodiesterase to calmodulin was determined and… Expand