H. Schulman

Publications111
h-index69
Citations18,726
Highly Influential Citations928
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The molecular basis of CaMKII function in synaptic and behavioural memory
Long-term potentiation (LTP) in the CA1 region of the hippocampus has been the primary model by which to study the cellular and molecular basis of memory. Calcium/calmodulin-dependent protein kinase… Expand
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Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP.
Long-term potentiation (LTP) of synaptic transmission is a widely studied cellular example of synaptic plasticity. However, the identity, localization, and interplay among the biochemical signals… Expand
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Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function.
Highly enriched in brain tissue and present throughout the body, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is central to the coordination and execution of Ca(2+) signal transduction. The… Expand
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Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II.
Ca2+/calmodulin (CaM)-dependent protein kinase (CaMKII) is a ubiquitous mediator of Ca2+-linked signalling that phosphorylates a wide range of substrates to co-ordinate and regulate Ca2+-mediated… Expand
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The multifunctional calcium/calmodulin-dependent protein kinase: from form to function.
The regulation of cellular function by hormones and extracellular molecules, which bind to cell surface receptors, is initiated by signal transduction mech­ anisms at the plasma membrane that lead to… Expand
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Calmodulin Trapping by Calcium-Calmodulin-Dependent Protein Kinase
Multifunctional calcium-calmodulin-dependent protein kinase (CaM kinase) transduces transient elevations in intracellular calcium into changes in the phosphorylation state and activity of target… Expand
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Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations.
The transduction of many cellular stimuli results in oscillations in the intracellular concentration of calcium ions (Ca2+). Although information is thought to be encoded in the frequency of such… Expand
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Transition from Reversible to Persistent Binding of CaMKII to Postsynaptic Sites and NR2B
Changes in protein–protein interactions and activity states have been proposed to underlie persistent synaptic remodeling that is induced by transient stimuli. Here, we show an unusual… Expand
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Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII.
Neurite extension and branching are important neuronal plasticity mechanisms that can lead to the addition of synaptic contacts in developing neurons and changes in the number of synapses in mature… Expand
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CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation
Ca2+-dependent facilitation (CDF) of voltage-gated calcium current is a powerful mechanism for up-regulation of Ca2+ influx during repeated membrane depolarization. CDF of L-type Ca2+ channels… Expand
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