calicheamicin theta(1)I

Known as: calicheamicin theta1 
 
National Institutes of Health

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AminoglycosidesEnediynes

Papers overview

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Review
2012
Review
2012
A total synthesis trilogy: calicheamicin γ1(I), Taxol®, and brevetoxin A.
Detailed behind-the-scenes accounts of the total syntheses of calicheamicin γ(1)(I), Taxol(®), and brevetoxin A are discussed… (More)
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2008
2008
Simultaneously targeting CD45 significantly increases cytotoxicity of the anti-CD33 immunoconjugate, gemtuzumab ozogamicin, against acute myeloid leukemia (AML) cells and improves survival of mice…
Targeting CD33 or CD45 is currently exploited for immunotherapy of acute myeloid leukemia (AML). Gemtuzumab ozogamicin (GO), an… (More)
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Highly Cited
2007
Highly Cited
2007
CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy.
Gemtuzumab ozogamicin (GO) contains an anti-CD33 antibody to facilitate uptake of a toxic calicheamicin-gamma(1) derivative… (More)
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Review
2007
Review
2007
Functions and regulation of human artemis in double strand break repair.
Cells, which lacked the activity of the nuclease Artemis, retained approximately 10% of unrepaired double strand breaks (DSBs) at… (More)
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Highly Cited
2004
Highly Cited
2004
Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity.
Gemtuzumab ozogamicin (GO; Mylotarg), a novel immunoconjugate used for treatment of acute myeloid leukemia (AML), contains the… (More)
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2003
2003
Cleavage of cellular DNA by calicheamicin gamma1.
It is assumed that the efficient antitumor activity of calicheamicin gamma1 is mediated by its ability to introduce DNA double… (More)
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2003
2003
Induction of apoptosis by enediyne antibiotic calicheamicin Ï‘II proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent manner
Calicheamicin ϑII is a member of the enediyne class of antitumor antibiotics that bind to DNA and induce apoptosis. These… (More)
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Highly Cited
2002
Highly Cited
2002
An anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia. Choice of linker.
The anti-CD33 antibody, P67.6, has been chosen to target the potently cytotoxic calicheamicin antitumor antibiotics to acute… (More)
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2000
2000
Targeted therapy of experimental renal cell carcinoma with a novel conjugate of monoclonal antibody 138H11 and calicheamicin thetaI1.
In search for a new therapeutic approach for metastasized renal cell carcinoma (RCC), we evaluated the cytotoxicity of a novel… (More)
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1998
1998
Targeted therapy with a novel enediyene antibiotic calicheamicin theta(I)1 effectively suppresses growth and dissemination of liver metastases in a syngeneic model of murine neuroblastoma.
The suppression of metastases in malignant diseases is one of the major goals in targeted chemotherapy. This was achieved with an… (More)
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