cabazitaxel

Known as: 1-hydroxy-7beta,10beta-dimethoxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,13alpha-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-{[(tertbutoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoate], 4-acetoxy-13-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate, Cabazitaxelum 
A semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND Androgen receptor splice variant 7 (AR-V7) in circulating tumor cells (CTCs) from patients with metastatic castration… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Prostate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We… (More)
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2015
2015
We studied mechanisms of resistance to the novel taxane cabazitaxel in established cellular models of taxane resistance. We also… (More)
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Highly Cited
2015
Highly Cited
2015
IMPORTANCE We previously showed that detection of androgen receptor splice variant 7 (AR-V7) in circulating tumor cells (CTCs… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Cabazitaxel, abiraterone acetate (AA), and enzalutamide have been approved for the treatment of patients with… (More)
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Review
2014
Review
2014
First-generation taxanes have changed the treatment paradigm for a wide variety of cancers, but innate or acquired resistance… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE Taxanes are important chemotherapeutic agents with proven efficacy in human cancers, but their use is limited by… (More)
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Review
2011
Review
2011
Until recently, patients with castration-resistant prostate cancer (CRPC) had limited therapeutic options once they became… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Cabazitaxel is a novel tubulin-binding taxane drug with antitumour activity in docetaxel-resistant cancers. We aimed… (More)
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Review
2010
Review
2010
Cabazitaxel is a new taxane characterized by convenient administration, a favorable pharmacokinetic and safety profile and a… (More)
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