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buclizine

Known as: 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)piperazine, Buclizinum, Aphilan-R Base 
A piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to and blocks the histamine H1… 
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (3)

AphilanSoftranVibazine
Buclizine hydrochlorideDrug AllergyHistamine H1 Receptor Antagonists [MoA]Motion Sickness

Broader (2)

Histamine AntagonistsPiperazines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Design, Synthesis and Relational Biological Evaluation of Novel Diphenylpiperazine 1,2,3-triazole Derivatives
A series of novel diphenylpiperazine 1,2,3-triazole derivatives were designed, synthesized and characterized by proton nuclear… 
2011
2011
Buclizine is back again! This time as a pediatric appetite stimulant
Sir, Buclizine is an antihistaminic drug which has been tried in several medical conditions with few or no success. These… 
2011
2011
High-performance column liquid chromatographic method for the simultaneous determination of buclizine, tryptophan, pyridoxine, and cyanocobalamin in tablets and oral suspension.
An HPLC method was developed and validated for the simultaneous determination of buclizine, tryptophan, pyridoxine, and… 
Review
2011
Review
2011
Preface to volume 36.
1995
1995
Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: Relation to lipophilicity and membrane effects
In a model for mucosal mast cells (RBL-2H3 cells) a set H1-antagonist derived anti-allergic drugs containing a diphenylmethyl… 
1985
1985
Acute toxicity and analgesic action of a combination of buclizine, codeine and paracetamol ('Migraleve') in tablet and suppository form in rats.
Studies in rats were carried out to determine the acute toxicity and analgesic effect of a combination preparation ('Migraleve… 
1969
1969
[Buclizine as an appetite stimulant. Clinical, experimental and toxicological studies].
1966
1966
Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse.
1960
1960
Comparison of excited phases alter sedatives and tranquilizers
Summary1.When compared on an activity table, mice given phenobarbital or ethanol show an initial excitatory phase.2.This… 
1954
1954
Pharmacological properties of two new antihistaminics of prolonged action.
A study was made of the pharmacological action of two new antihistaminic compounds of prolonged action. These compounds contain… 
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