brostallicin

Known as: 4-(2-Bromoacrylamido)-N'''-(2-guanidinoethyl)-1,1',1',1'''-tetramethyl-N,4':N',4':N',4'''-quater(pyrrole-2-carboxamide) 
A synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2013
02420012013

Papers overview

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2013
2013
Brostallicin is a DNA minor groove binder that shows enhanced antitumor activity in cells with high glutathione S-transferase… (More)
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2010
2010
Brostallicin is a novel and unique glutathione transferase-activated pro-drug with promising anticancer activity, currently in… (More)
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2009
2009
Brostallicin (PNU-166196), a-bromo-acrylamido tetra-pyrrole derivative, showed high cytotoxic potency and myelotoxicity… (More)
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2009
2009
Brostallicin is a DNA minor groove binder in phase II clinical trials. Here, we show that brostallicin induces gamma-H2AX nuclear… (More)
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2006
2006
The cytotoxic activity of Brostallicin was previously shown to be enhanced in the presence of high glutathione and glutathione… (More)
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2004
2004
PURPOSE This study was performed to determine the maximum tolerated dose, dose-limiting toxicities, and pharmacokinetics of… (More)
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2003
2003
Defects in DNA mismatch repair (MMR) are associated with a predisposition to tumorigenesis and with drug resistance owing to high… (More)
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2003
2003
PURPOSE Brostallicin (PNU-166196) is a alpha-bromoacrylic DNA minor groove binder, currently in clinical evaluation. This drug… (More)
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2003
2003
PURPOSE Brostallicin (PNU-166196) is a cytotoxic agent that binds to the minor groove of DNA with significant antitumor activity… (More)
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2002
2002
Brostallicin (PNU-166196) is a synthetic alpha-bromoacrylic, second-generation DNA minor groove binder structurally related to… (More)
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