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brostallicin

Known as: 4-(2-Bromoacrylamido)-N'''-(2-guanidinoethyl)-1,1',1',1'''-tetramethyl-N,4':N',4':N',4'''-quater(pyrrole-2-carboxamide) 
A synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (2)

Brostacillin HydrochloridePNU 166196

Broader (2)

GuanidinesPyrroles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Thiol-activated DNA damage by α-bromo-2-cyclopentenone.
Some biologically active chemicals are relatively stable in the extracellular environment but, upon entering the cell, undergo… 
2010
2010
Brostallicin versus doxorubicin as first-line chemotherapy in patients with advanced or metastatic soft tissue sarcoma: An EORTC Soft Tissue and Bone Sarcoma Group randomized phase II study.
10037 Background: Brostallicin (B) is a DNA minor groove binder which showed activity in a recent phase II study in patients with… 
2009
2009
Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin
Brostallicin is a DNA minor groove binder in phase II clinical trials. Here, we show that brostallicin induces γ-H2AX nuclear… 
Review
2007
Review
2007
Systemic treatment options for patients with refractory adult-type sarcoma beyond anthracyclines
For the subgroup of patients with inoperable gastrointestinal stromal tumors, progress has been made by the rapid development and… 
2006
2006
Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity.
Review
2004
Review
2004
Brostallicin: a new concept in minor groove DNA binder development
Brostallicin is a bromoacryloyl derivative of distamycin A, which has shown very promising preclinical activity against a variety… 
2003
2003
Enhancement of in vivo antitumor activity of classical anticancer agents by combination with the new, glutathione-interacting DNA minor groove-binder, brostallicin.
PURPOSE Brostallicin (PNU-166196) is a alpha-bromoacrylic DNA minor groove binder, currently in clinical evaluation. This drug… 
2003
2003
Phase I and pharmacokinetic study of brostallicin (PNU-166196), a new DNA minor-groove binder, administered intravenously every 3 weeks to adult patients with metastatic cancer.
PURPOSE Brostallicin (PNU-166196) is a cytotoxic agent that binds to the minor groove of DNA with significant antitumor activity… 
2003
2003
LC-MS-MS determination of brostallicin in human plasma following automated on-line SPE.
2002
2002
Cytotoxic alpha-bromoacrylic derivatives of low molecular weight.
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