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PNU 166196

Known as: PNU-166196, PNU166196 
National Institutes of Health

Papers overview

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2009
2009
Brostallicin (PNU-166196), a-bromo-acrylamido tetra-pyrrole derivative, showed high cytotoxic potency and myelotoxicity… 
2004
2004
The mechanism of action of many antitumor agents involves DNA damage, either by direct binding of the drug to DNA or to DNA… 
2003
2003
Defects in DNA mismatch repair (MMR) are associated with a predisposition to tumorigenesis and with drug resistance owing to high… 
2003
2003
PURPOSE Brostallicin (PNU-166196) is a cytotoxic agent that binds to the minor groove of DNA with significant antitumor activity… 
2003
2003
PURPOSE Brostallicin (PNU-166196) is a alpha-bromoacrylic DNA minor groove binder, currently in clinical evaluation. This drug… 
2003
2003
Purpose: Brostallicin (PNU-166196) is a cytotoxic agent that binds to the minor groove of DNA with significant antitumor activity… 
Highly Cited
2002
Highly Cited
2002
Brostallicin (PNU-166196) is a synthetic alpha-bromoacrylic, second-generation DNA minor groove binder structurally related to… 
2002
2002
Review
2001
Review
2001
The relatively low therapeutic index of the clinically used alkylating agents is probably related to the fact that these…