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PNU 166196
Known as:
PNU-166196
, PNU166196
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
brostallicin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Brostallicin (PNU-166196), a new minor groove DNA binder: preclinical and clinical activity
D. Lorusso
,
S. Mainenti
,
+4 authors
G. Scambia
Expert Opinion on Investigational Drugs
2009
Corpus ID: 24536120
Brostallicin (PNU-166196), a-bromo-acrylamido tetra-pyrrole derivative, showed high cytotoxic potency and myelotoxicity…
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2004
2004
Cytotoxic alpha-halogenoacrylic derivatives of distamycin A and congeners.
I. Beria
,
P. Baraldi
,
+5 authors
R. Romagnoli
Journal of Medicinal Chemistry
2004
Corpus ID: 22983189
The mechanism of action of many antitumor agents involves DNA damage, either by direct binding of the drug to DNA or to DNA…
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2003
2003
Brostallicin (PNU-166196) – a new DNA minor groove binder that retains sensitivity in DNA mismatch repair-deficient tumour cells
A. Fedier
,
C. Fowst
,
+4 authors
D. Fink
British Journal of Cancer
2003
Corpus ID: 11841554
Defects in DNA mismatch repair (MMR) are associated with a predisposition to tumorigenesis and with drug resistance owing to high…
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2003
2003
Phase I and pharmacokinetic study of brostallicin (PNU-166196), a new DNA minor-groove binder, administered intravenously every 3 weeks to adult patients with metastatic cancer.
A. T. Ten Tije
,
J. Verweij
,
+10 authors
M. D. de Jonge
Clinical Cancer Research
2003
Corpus ID: 17528828
PURPOSE Brostallicin (PNU-166196) is a cytotoxic agent that binds to the minor groove of DNA with significant antitumor activity…
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2003
2003
Enhancement of in vivo antitumor activity of classical anticancer agents by combination with the new, glutathione-interacting DNA minor groove-binder, brostallicin.
M. Sabatino
,
T. Colombo
,
C. Geroni
,
S. Marchini
,
M. Broggini
Clinical Cancer Research
2003
Corpus ID: 42592826
PURPOSE Brostallicin (PNU-166196) is a alpha-bromoacrylic DNA minor groove binder, currently in clinical evaluation. This drug…
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2003
2003
Phase I and Pharmacokinetic Study of Brostallicin ( PNU-166196 ) , a New DNA Minor-Groove Binder , Administered Intravenously Every 3 Weeks to Adult Patients with Metastatic Cancer 1
A. Tije
,
J. Verweij
,
+10 authors
M. D. Jonge
2003
Corpus ID: 10273075
Purpose: Brostallicin (PNU-166196) is a cytotoxic agent that binds to the minor groove of DNA with significant antitumor activity…
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Highly Cited
2002
Highly Cited
2002
Brostallicin, a novel anticancer agent whose activity is enhanced upon binding to glutathione.
C. Geroni
,
S. Marchini
,
+7 authors
M. Broggini
Cancer Research
2002
Corpus ID: 39963446
Brostallicin (PNU-166196) is a synthetic alpha-bromoacrylic, second-generation DNA minor groove binder structurally related to…
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2002
2002
Cytotoxic alpha-bromoacrylic derivatives of low molecular weight.
I. Beria
,
M. Caldarelli
,
+4 authors
P. Cozzi
Bioorganic & Medicinal Chemistry Letters
2002
Corpus ID: 25395858
2001
2001
A new class of cytotoxic DNA minor groove binders: alpha-halogenoacrylic derivatives of pyrrolecarbamoyl oligomers.
P. Cozzi
Il Farmaco
2001
Corpus ID: 41681998
Review
2001
Review
2001
Development of distamycin-related DNA binding anticancer drugs
S. Marchini
,
M. Broggini
,
C. Sessa
,
M. D’Incalci
Expert Opinion on Investigational Drugs
2001
Corpus ID: 35281246
The relatively low therapeutic index of the clinically used alkylating agents is probably related to the fact that these…
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