PNU 166196

Known as: PNU-166196, PNU166196 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2009
01220002009

Papers overview

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2009
2009
Brostallicin (PNU-166196), a-bromo-acrylamido tetra-pyrrole derivative, showed high cytotoxic potency and myelotoxicity… (More)
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2004
2004
The mechanism of action of many antitumor agents involves DNA damage, either by direct binding of the drug to DNA or to DNA… (More)
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2003
2003
Defects in DNA mismatch repair (MMR) are associated with a predisposition to tumorigenesis and with drug resistance owing to high… (More)
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2003
2003
PURPOSE Brostallicin (PNU-166196) is a cytotoxic agent that binds to the minor groove of DNA with significant antitumor activity… (More)
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2003
2003
PURPOSE Brostallicin (PNU-166196) is a alpha-bromoacrylic DNA minor groove binder, currently in clinical evaluation. This drug… (More)
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Review
2003
Review
2003
DNA minor groove binders (MGB) represent a class of anticancer agents whose DNA sequence specificity was hypothesized to lead to… (More)
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2002
2002
Brostallicin (PNU-166196) is a synthetic alpha-bromoacrylic, second-generation DNA minor groove binder structurally related to… (More)
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2001
2001
DNA minor groove binders represent a class of cytotoxic antitumor agents whose DNA sequence specificity may lead to a high… (More)
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Review
2001
Review
2001
The relatively low therapeutic index of the clinically used alkylating agents is probably related to the fact that these… (More)
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2000
2000
The design, synthesis, in vitro and in vivo activities of novel alpha-bromoacrylic derivatives of distamycin A, modified at the… (More)
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