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PNU 166196

Known as: PNU-166196, PNU166196 
National Institutes of Health

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Broader (1)

brostallicin

Papers overview

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Review
2009
Review
2009
alpha-halogenoacrylic derivatives of antitumor agents.
In this review article we have reported a series of hybrid compounds characterized by the presence of a alpha-halogenocryloyl… 
2007
2007
PNU-166196 induces DNA damage measured by histone H2AX phosphorylation independently of the nucleotide excision repair pathways.
B77 PNU-166196 is a DNA minor groove binder in Phase II clinical development. Data suggest that PNU-166196 is activated by… 
2003
2003
Phase I and pharmacokinetic study of brostallicin (PNU-166196), a new DNA minor-groove binder, administered intravenously every 3 weeks to adult patients with metastatic cancer.
PURPOSE Brostallicin (PNU-166196) is a cytotoxic agent that binds to the minor groove of DNA with significant antitumor activity… 
2003
2003
Enhancement of in vivo antitumor activity of classical anticancer agents by combination with the new, glutathione-interacting DNA minor groove-binder, brostallicin.
PURPOSE Brostallicin (PNU-166196) is a alpha-bromoacrylic DNA minor groove binder, currently in clinical evaluation. This drug… 
2003
2003
Phase I and Pharmacokinetic Study of Brostallicin ( PNU-166196 ) , a New DNA Minor-Groove Binder , Administered Intravenously Every 3 Weeks to Adult Patients with Metastatic Cancer 1
Purpose: Brostallicin (PNU-166196) is a cytotoxic agent that binds to the minor groove of DNA with significant antitumor activity… 
2002
2002
Cytotoxic alpha-bromoacrylic derivatives of low molecular weight.
2001
2001
A new class of cytotoxic DNA minor groove binders: alpha-halogenoacrylic derivatives of pyrrolecarbamoyl oligomers.
2001
2001
Brostallicin (PNU-166196), a DNA minor groove binder characterized by alpha-halogenoacrylamide moiety linked to tetrapyrrole frame, shows unusual mechanistic features.
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