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borrelidin

Known as: 2-(7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)-cyclopentanecar boxylic acid 
National Institutes of Health

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Fatty Alcohols

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Isolation of borrelidin from Streptomyces californicus—An Indian soil isolate
In a screening programme for search of antibiotics active against clinical resistant strains of infectious bacteria, a potent… 
2006
2006
Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues.
We report the directed biosynthesis of borrelidin analogues and their selective anti-proliferative activity against human cancer… 
2004
2004
Effect of borrelidin on the threonyl-tRNA-synthetase activity and the regulation of threonine-biosynthetic enzymes in Saccharomyces cerivisiae
SummaryIn yeast cells grown in the presence of Borrelidin the threonyl-tRNA-synthetase is inhibited and a specific derepression… 
Highly Cited
2003
Highly Cited
2003
Enantioselective total synthesis of borrelidin.
The first total synthesis of the natural product borrelidin is described. The propionate fragment of the molecule was concisely… 
Highly Cited
2003
Highly Cited
2003
Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of…
Borrelidin, an antibiotic with anti-angiogenic activity, not only suppresses new capillary tube formation, but also collapses… 
Highly Cited
2003
Highly Cited
2003
Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase.
Functional evidence for programmed loss of co-linearity on the borrelidin modular polyketide synthase (PKS) is presented. 
2001
2001
Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae.
We identified borrrelidin, a member of macrolide antibiotic, as an inhibitor of a cyclin-dependent kinase of the budding yeast… 
Highly Cited
1997
Highly Cited
1997
Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model.
Borrelidin, an antibiotic from Streptomyces rochei, was found to be an angiogenesis inhibitor in a rat aorta matrix culture model… 
1981
1981
Increased levels of threonyl-tRNA synthetase in a borrelidin-resistant Chinese hamster ovary cell line.
The growth of Chinese hamster ovary cells in medium containing reduced concentrations of threonine is inhibited by borrelidin, a… 
1965
1965
Isolation of Vivomycin and Borrelidin, Two Antibiotics with Anti-Viral Activity, from a Species of Streptomyces (C2989)
Isolation of Vivomycin and Borrelidin, Two Antibiotics with Anti-Viral Activity, from a Species of Streptomyces (C2989) 
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