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Streptovirudins, new antibiotics with antibacterial and antiviral activity. II. Isolation, chemical characterization and biological activity of streptovirudins A1, A2, B1, B2, C1, C2, D1, and D2.
The streptovirudins are chemically and biologically related to each other and appear to be a new family of antibiotics exhibiting activity against a variety of Gram-positive bacteria, mycobacteria, and various DNA- and RNA-viruses. Expand
The antiviral activity of dipyridamole.
Dipyridamole, a coronary vasodilatator, was found to possess antiviral activity against representatives of different families, and significantly inhibited the yield of members of the viral families Picornaviridae, Togaviraceae, Orthomyxovir Families, ParamyxovIRidae, Herpetoviridae and Poxviridae. Expand
[Investigations of the isothiocyanates erysolin and sulforaphan of Cardaria draba L].
Streptovirudins, new antibiotics with antibacterial and antiviral activity. I. Culture taxonomy, fermentation and production of streptovirudin complex.
The antibiotic complex, designated as streptovirudin, was isolated from extracts of both mycelium and culture filtrate and exhibits antibiotic activity against Gram-positive bacteria, mycobacteria, and various DNA- and RNA-viruses. Expand
On the antiviral activity of diffusomycin (oxazolomycin).
The effect of the beta-lactone antibiotic diffusomycin (oxazolomycin) was investigated against vaccinia (Lister), herpes simplex type 1 (Kupka), influenza A, influenza A (WSN; H1N1), and Coxsackie A9 viruses, finding a reduced synthesis of HSV-1 nucleocapsids in dependence on the concentration of the compound. Expand
Antiviral action of dipyridamole and its derivatives against influenza virus A.
Dipyridamole proved to be active against influenza viruses A/England 42/72, A/Bangkok 1/79 and A/fowl plague (FPV) and no inhibition was found against influenza virus B/Leningrad 235/74 in vitro. Expand
Inhibitory activity of 2-aminooxazole derivatives against Coxsackie B1 virus in FL cells.
The antiviral activity of three-2-aminooxazoles was studied against coxsackie B1 virus in FL cells and the results suggested an inhibition of uridine transport. Expand
Induction of lymphokines by tilorone.
- B. Fahlbusch, W. Zschiesche, I. Schumann, E. Tonew
- Biology, Medicine
- Archivum immunologiae et therapiae experimentalis
Kinetic studies showed a close correspondence between interferon and MIF serum levels and the physiochemical characteristics of tilorone-induced MIF (heat and pH lability, molecular size) are compared with those of MIF generated in in vitro lymphocyte cultures. Expand
Streptovirudins -- new antibiotics with antiviral activity. The antiviral spectrum and inhibition of Newcastle disease virus in cell cultures.
The antibiotics failed to show a direct virucidal effect on the NDV virion itself or to influence virus adsorption and penetration processes, and addition of streptovirudin complex during a one-step growth cycle of NDV from 0-4 hours after virus adsorbption resulted in complete suppression of virus yield. Expand
Cyclic AMP metabolism and interferon induction in mice after treatment with 10-carboxymethyl-9-acridanone.
The low molecular weight substance 10-carboxymethyl-9-acridanone acted as an inhibitor of low Km cAMP phosphodiesterase in cell homogenates and significantly enhanced enzyme activity was found after exposure to CMA in vivo. Expand