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bolinaquinone

 
National Institutes of Health

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Sesquiterpenes

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2018
2018
A focused library synthesis and cytotoxicity of quinones derived from the natural product bolinaquinone
Bolinaquinone is a natural product that is a structurally complex, cytotoxic sesquiterpene quinone. A scaffold simplification and… Expand
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2014
2014
In Silico Docking, Molecular Dynamics and Binding Energy Insights into the Bolinaquinone-Clathrin Terminal Domain Binding Site
Clathrin-mediated endocytosis (CME) is a process that regulates selective internalization of important cellular cargo using… Expand
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2011
2011
Chemical proteomics reveals bolinaquinone as a clathrin-mediated endocytosis inhibitor.
The emerging field of mass spectrometry-based chemical proteomics provides a powerful instrument in the target discovery of… Expand
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2011
2011
Structure-based design, synthesis and preliminary anti-inflammatory activity of bolinaquinone analogues.
As a part of our drug discovery efforts we developed a series of simplified derivatives of bolinaquinone (BLQ), a hydroxyquinone… Expand
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2009
2009
The molecular mechanism of human group IIA phospholipase A2 inactivation by bolinaquinone.
The molecular basis of the human group IIA secretory phospholipase A(2) inactivation by bolinaquinone (BLQ), a hydroxyquinone… Expand
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2009
2009
Dysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death.
In the course of our search for neuroprotective agents, dysideamine (1), a new sesquiterpene aminoquinone, was isolated along… Expand
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2006
2006
The molecular mechanism of bee venom phospholipase A2 inactivation by bolinaquinone.
The molecular basis of the inactivation of bee venom PLA2 by the marine natural product bolinaquinone (BLQ) was studied by… Expand
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2005
2005
Protection against 2,4,6-trinitrobenzenesulphonic acid-induced colonic inflammation in mice by the marine products bolinaquinone and petrosaspongiolide M.
Proinflammatory mediators, namely eicosanoids, reactive oxygen and nitrogen species and cytokines, are clearly involved in the… Expand
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2003
2003
Modulatory effect of bolinaquinone, a marine sesquiterpenoid, on acute and chronic inflammatory processes.
The marine metabolite bolinaquinone is a novel inhibitor of secretory phospholipase A(2) (sPLA(2)), with a potency on the human… Expand
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2001
2001
New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte functions.
Two new sesquiterpene cyclopentenones, dysidenones A and B (2, 3), and a new sesquiterpene aminoquinone, dysidine (4), all… Expand
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