boceprevir

Known as: 3-Azabicyclo(3.1.0)hexane-2-carboxamide, N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-((2S)-2-((((1,1- dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6- dimethyl-, (1R,2S,5S)-, N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide 
An orally bioavailable, synthetic tripeptide inhibitor of the nonstructural protein 3 and 4A complex (NS3/NS4A), with potential activity against… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND & AIMS We investigated the effectiveness of the protease inhibitors peginterferon and ribavirin in treatment… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND All-oral combination therapy is desirable for patients with chronic hepatitis C virus (HCV) infection. We evaluated… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Rates of sustained virological response (SVR) to peginterferon-ribavirin are low in patients with hepatitis C virus… (More)
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2013
2013
BACKGROUND We investigated the frequency of RAVs among patients failing to achieve SVR in two clinical trials. We also… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND & AIMS Little is known about factors associated with a sustained virologic response (SVR) among patients with… (More)
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Highly Cited
2012
Highly Cited
2012
UNLABELLED Randomized controlled trials (RCTs) show that triple therapy (TT) with peginterferon alpha, ribavirin, and boceprevir… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Peginterferon-ribavirin therapy is the current standard of care for chronic infection with hepatitis C virus (HCV… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND In patients with chronic infection with hepatitis C virus (HCV) genotype 1 who do not have a sustained response to… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Peginterferon plus ribavirin achieves sustained virological response (SVR) in fewer than half of patients with… (More)
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Highly Cited
2009
Highly Cited
2009
UNLABELLED Boceprevir is a hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor that is currently being… (More)
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