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bindarit

Known as: AF 2838, AF-2838, 2-((1-benzyl-3-indazolyl)methoxy)-2-methylpropionic acid 
National Institutes of Health

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2 relations

Broader (2)

IndazolesPropionates

Papers overview

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Highly Cited
2014
Highly Cited
2014
Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection
ABSTRACT The recent global resurgence of arthritogenic alphaviruses, in particular chikungunya virus (CHIKV), highlights an… 
Highly Cited
2012
Highly Cited
2012
Bindarit: an anti-inflammatory small molecule that modulates the NFκB pathway.
The activation of nuclear factor (NF)κB pathway and its transducing signaling cascade has been associated with the pathogenesis… 
Highly Cited
2011
Highly Cited
2011
Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis.
Chikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans. Using a mouse model of CHIKV… 
Highly Cited
2009
Highly Cited
2009
Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteins.
OBJECTIVE Alphaviruses such as chikungunya virus, Sindbis virus, o'nyong-nyong virus, Mayaro virus, and Ross River virus (RRV… 
Highly Cited
2009
Highly Cited
2009
The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice
Aims Bindarit is an original compound with peculiar anti-inflammatory activity due to a selective inhibition of a subfamily of… 
Highly Cited
2008
Highly Cited
2008
Role of MCP-1 in endotoxemia and sepsis.
Highly Cited
2008
Highly Cited
2008
Impact of the anti-inflammatory agent bindarit on the chemokinome: selective inhibition of the monocyte chemotactic proteins.
Bindarit is an indazolic derivative that is devoid of any immunosuppressive effects and has no effect on arachidonic acid… 
Highly Cited
2005
Highly Cited
2005
Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis.
Chemokines are believed to play a key role in the pathogenesis of acute pancreatitis. We have earlier shown that pancreatic… 
Highly Cited
2002
Highly Cited
2002
Amelioration of rat adjuvant arthritis by therapeutic treatment with bindarit, an inhibitor of MCP-1 and TNF-α production
Abstract. Objective: This study was designed to evaluate therapeutic effects of bindarit, an indazolic derivative able to inhibit… 
Highly Cited
1998
Highly Cited
1998
Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease.
As an alternative to classical immunosuppressants in experimental lupus nephritis, we looked at bindarit, 2-methyl-2-[[1… 
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