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bidisomide

Known as: alpha-(2-(acetyl(1-methylethyl)amino)ethyl)-alpha-(2-chlorophenyl)-1-piperidinebutanamide 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Anti-Arrhythmia AgentsPiperidines

Narrower (2)

SC 40230bidisomide, (-)-isomer

Papers overview

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2005
2005
Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine…
SummaryWe investigated the antiarrhythmic effects of bidisomide (SC-40230), a new class I antiarrhythmic drug, in early-phase… 
1999
1999
Application of sulfobutylether‐β‐cyclodextrin with specific degrees of substitution for the enantioseparation of pharmaceutical mixtures by capillary electrophoresis
In this research the separation of the enantiomers of the basic drug bidisomide (SC‒40230) from five closely related known… 
1998
1998
Reduced Systemic Availability of an Antiarrhythmic Drug, Bidisomide, with Meal Co-administration: Relationship with Region-Dependent Intestinal Absorption
AbstractPurpose. The aim of this research was to determine the mechanism by which a co-administered meal decreases the oral… 
1998
1998
Mechanism of Compound- and Species-Specific Food Effects of Structurally Related Antiarrhythmic Drugs, Disopyramide and Bidisomide
AbstractPurpose. To determine mechanism of food effects observed with bidisomide but not with the structurally similar drug… 
1997
1997
Treatment of atrial fibrillation and paroxysmal supraventricular tachycardia with bidisomide. The Atrial Fibrillation Investigation with Bidisomide (AFIB) Investigators.
BACKGROUND Atrial fibrillation and paroxysmal supraventricular tachycardia are common disorders of the heart rhythm for which… 
1997
1997
Mechanisms of Food Effects of Structurally Related Antiarrhythmic Drugs, Disopyramide and Bidisomide in the Rat
AbstractPurpose. To determine whether the rat is a good animal model for the food effects observed with bidisomide but not with… 
1996
1996
Comparison of bidisomide, flecainide and dofetilide on action potential duration in isolated canine atria: effect of isoproterenol.
Prolongation of action potential duration (APD) and the effective refractory period (ERP) is one mechanism to prevent reentrant… 
1993
1993
Absorption and Disposition of a New Antiarrhythmic Agent Bidisomide in Man
Absorption and disposition of bidisomide were studied in 12 healthy male subjects after a 20-min iv (1 mg/kg; N = 6) infusion and… 
1993
1993
The Effect of Bidisomide (SC‐40230), a New Class Ia/Ib Antiarrhythmic Agent, on Defihrillation Energy Requirements in Dogs with Healed Myocardial Infarctions
Bidisomide is a Class Ia/Ib antiarrhythmic agent with activity against ventricular and supraventricular arrhythmias. The… 
1992
1992
Rapid Infusions of Bidisomide or Disopyramide in Conscious Dogs: Effect of Myocardial Infarction on Acute Tolerability
Summary The acute tolerability of rapid infusions of bidisomide or disopyramide was evaluated in normal conscious dogs and in… 
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