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bidisomide

Known as: alpha-(2-(acetyl(1-methylethyl)amino)ethyl)-alpha-(2-chlorophenyl)-1-piperidinebutanamide 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Anti-Arrhythmia AgentsPiperidines

Narrower (2)

SC 40230bidisomide, (-)-isomer

Papers overview

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2005
2005
Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine…
SummaryWe investigated the antiarrhythmic effects of bidisomide (SC-40230), a new class I antiarrhythmic drug, in early-phase… 
1998
1998
Reduced Systemic Availability of an Antiarrhythmic Drug, Bidisomide, with Meal Co-administration: Relationship with Region-Dependent Intestinal Absorption
AbstractPurpose. The aim of this research was to determine the mechanism by which a co-administered meal decreases the oral… 
1998
1998
Mechanism of Compound- and Species-Specific Food Effects of Structurally Related Antiarrhythmic Drugs, Disopyramide and Bidisomide
AbstractPurpose. To determine mechanism of food effects observed with bidisomide but not with the structurally similar drug… 
1997
1997
Treatment of atrial fibrillation and paroxysmal supraventricular tachycardia with bidisomide. The Atrial Fibrillation Investigation with Bidisomide (AFIB) Investigators.
BACKGROUND Atrial fibrillation and paroxysmal supraventricular tachycardia are common disorders of the heart rhythm for which… 
1997
1997
Mechanisms of Food Effects of Structurally Related Antiarrhythmic Drugs, Disopyramide and Bidisomide in the Rat
AbstractPurpose. To determine whether the rat is a good animal model for the food effects observed with bidisomide but not with… 
1993
1993
Absorption and Disposition of a New Antiarrhythmic Agent Bidisomide in Man
Absorption and disposition of bidisomide were studied in 12 healthy male subjects after a 20-min iv (1 mg/kg; N = 6) infusion and… 
1993
1993
Importance of pharmacokinetic and physicochemical data in the discovery and development of novel anti-arrhythmic drugs.
1. The importance of pharmacokinetics and physicochemical data in the discovery and development of a new mono-cationic… 
1992
1992
Rapid Infusions of Bidisomide or Disopyramide in Conscious Dogs: Effect of Myocardial Infarction on Acute Tolerability
Summary The acute tolerability of rapid infusions of bidisomide or disopyramide was evaluated in normal conscious dogs and in… 
1992
1992
Electropharmacology of bidisomide in the normal intact canine heart
Bidisomide (SC‐40230) is a class I antiarrhythmic agent. The effects of bidisomide on the electrophysiology of the intact heart… 
1992
1992
Clinical evaluation of bidisomide, a new class I antiarrhythmic: Initial intravenous dose‐finding study
To assess effectiveness and tolerability of intravenous bidisomide, 16 patients (aged 57 ± 15 years) with ≥ 100 premature… 
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