Semantic Scholar uses AI to extract papers important to this topic.
Internalization of β-adrenergic receptors (βARs) occurs by the sequential binding of β-arrestin, the clathrin adaptor AP-2, and… Expand Background — Genetic manipulation to reverse molecular abnormalities associated with dysfunctional myocardium may provide novel… Expand Background—Acute cardiac contractile dysfunction is common after cardiopulmonary bypass (CPB). A potential molecular mechanism is… Expand Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR) function, which includes loss of betaAR… Expand We studied the effect of alterations in the level of myocardial β-adrenergic receptor kinase (βARK1) in two types of genetically… Expand BACKGROUND
Impaired myocardial beta-adrenergic receptor (betaAR) signaling, including desensitization and functional uncoupling… Expand Cardiovascular gene therapy is a novel approach to the treatment of diseases such as congestive heart failure (CHF). Gene… Expand The α-adrenergic receptor (αAR), its truncated mutant T368, different G protein-coupled receptor kinases (GRK) and arrestin… Expand We have studied the ligand-induced phosphorylation/dephosphorylation of the bradykinin B2 receptor endogenously expressed in… Expand G protein-coupled receptor kinases (GRKs) are implicated in the homologous desensitization of G protein-coupled receptors. Six… Expand